Introduction
Staphylococcus aureus colonization is a risk factor for endogenous staphylococcal infection in vulnerable neonates. Several studies describe prophylactic measures for adult population, but very few recommendations are establish for neonatal intensive care unit (NICU). After detecting an increase in severe S. aureus infection in the NICU, the present study has the objective to check if a bundle of measures to decrease S aureus c olonization in NICU babies have impact in reducing infection.