Ninety-seven CRGNinf were detected (0.2%), 40 (41.2%) associated with patient’s death. CRGNinf prolonged LoS by 14.2 days (95% confidence interval (CI) 8.1-20.2) compared to uninfected patients. The inclusion of CRGNinf as a time-dependent variable in a multivariate Cox proportional hazards model confirmed that the occurrence of infection significantly reduced the hazard of end of hospital stay and consequently prolonged LoS in hospital compared to uninfected patients (hazard ratio (HR) 0.60, 95% CI 0.49-0.74). When stratifying the analysis by outcome (discharge or death), CRGNinf was associated with a further reduced risk of discharge from hospital (adjusted HR 0.39, 95% CI 0.30-0.51) and, in parallel, to a significant higher risk of end of hospital stay because of death (adjusted HR 3.45, 95% CI 2.49-4.77).