There was a significant decrease in central venous catheter-related bloodstream infection (CRBSI) rates following the programme implementation. CRBSI rates fell from 5.4 infections / 1,000 CVC days (95% confidence interval (CI) 3.1 – 9.5) in the baseline period to 0.8 (95% CI 0.3 – 2.1) during the 18 months of the programme. Hand hygiene compliance rates rose from 48.8% (baseline period) to 77.2% during the period of programme implementation, with results maintaining above 75% in the latter 12 months (Jan – Dec 2012). Factors facilitating itsimplementation include institutional endorsement of outcome measures as key performance indicators, regular feedback to stakeholders, targeted educational sessions, and bedside shadowing exercises. Challenges have also been encountered, eg. maintaining motivation and enthusiasm of staff, waning of the ‘novelty’ factor in the study, maintaining hand hygiene as a priority in challenging times, poorer compliance rates of visiting medical teams.