Of the 217 patients with CRSAB, follow-up BCs were performed in 175 patients (81%) between 48 and 96 hours. Of these 175 patients, follow-up BCs were positive in 74 (42%) and negative in 101 (58%) patients. Follow-up BCs was more like to have positive results in episodes of CRSABs caused by methicillin-resistant isolates than those caused by methicillin-susceptible isolates (86.5% vs. 57.3%; P < 0.001). Cardiac echocardiography to detect infective endocarditis was more likely to be performed in patients with positive follow-up BCs than in patients with negative follow-up BCs (87.8% vs. 68.3%; P = 0.003). Complication occurred in 54% of patients with positive follow-up BC results and in 13% of patients with negative follow-up BC results (P < 0.001). Eight (18%) of the 74 patients with positive follow-up BC result experienced the recurrence, but 1 (1%) of the 111 patients with negative follow-up BC result experienced recurrence (P = .005).