Invasive Device Associated Infection (IDAI) rate in healthcare facilities is one of the important quality indicators. IDAI rate should be monitored and necessary precautions should be implemented. Surveillance for IDAI has been started in 2001 at Hacettepe University (H.U.) intensive care units (ICU). When compared the year 2001 to 2005 surveillance results with other reports it was seen as higher than developed countries. In 2006 Ventilator-associated pneumonia (VAP) rate was doubled than 90 percentiles therefore a several interventions were conducted to decrease VAP and Central Line-Associated Bloodstream Infection (CLABSI) rate in all ICUs since 2007.