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  • Open Access

P022: Antibiograms of consecutive urinary tract samples in elderly

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Antimicrobial Resistance and Infection Control20132 (Suppl 1) :P22

  • Published:


  • Urinary Tract Infection
  • Ampicillin
  • Antimicrobial Resistance
  • Cefuroxime
  • Empiric Therapy


Urinary tract infections are the main indication for antimicrobials in elderly.


Despite the treat for resistance dissemination and therapy failure, clinicians are seldom informed on the per patient evolution of antimicrobial resistance in pathogens.


Laboratory results were obtained from 13 voluntary diagnostic laboratories (12 hospital-associated) in Belgium during the year 2005. Susceptibility profiles were done by Kirby Bauer disk diffusion according to CLSI. The first two urine samples from patients older than 65 year were included.


Following organisms were predominantly isolated (N first samples/N second samples): E. coli (7188/1654), E. faecalis (1282/403), P. mirabilis (1230/313), K. pneumonia (673/173), P. aeruginosa (293/120), E. aerogenes (375/203), S. aureus (158/54), M. morganii (347/89), Group B streptococci (149/31), C. freundii complex (101/29). When comparing first versus second samples antibiograms for E. coli, a decrease in susceptibility was found for the following antimicrobial agents: cotrimoxazole -6.9%; nitrofurantoin -2.8%, fosfomycin 0.0%; ciprofloxacin -10.8%; cefuroxime -5.6%; amoxicillin-clavulanic acid -5.6%; ampicillin -10.5%. For E. faecalis, marked decreases were found for nitrofurantoin -2.4%; fosfomycin -2.2%; -ciprofloxacin -10.3%; and only mild decreases for amoxicillin-clavulanic acid 0.0%; and ampicillin -1.2%. For K. pneumoniae decreases were in the range of -2.9 to -4.1% for cotrimoxazole, ciprofloxacine, cefuroxime and amoxicillin-clavulanic acid, and was -12.4% for nitrofurantoin. For S. aureus and C. freundii no decrease (<-0.1%) was seen for nitrofurantoin and fosfomycin. For E. aerogenes, decreases of -18 and -12.5% were found for cotrimoxazole and fosfomycin, respectively. M. morganii showed in consecutive samples less susceptibility for cotrimoxazole (-16.2%), fosfomycine (-13.0%) and ciprofloxacin (-10.5%), while only a marginal decrease was found for nitrofurantoin (-0.5%).


The resistance selection influence of consecutive samples depends on the antibiotic-bacterium combinations, and thus might be taken into account when empiric therapy guidelines for urinary tract infections in elderly are reviewed.

Disclosure of interest

None declared

Authors’ Affiliations

Healthcare Associated Infections (NSIH), Brussels, Belgium
Scientific Institute of Public Health, Brussels, Belgium
University of Antwerp, Wilrijk, Brussels, Belgium
Intermutualistic Agency, Brussels, Belgium


© Latour et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.