We identified 1431 sources; of the 124 included, 70 reported serotype data in children and adults with IPD from 15 countries. Before PCV introduction, PCV7 and PCV13 serotypes represented 53-77% and 91% of those found in children and 14-46% and 75% in adults, respectively. After PCV7 introduction this changed to 1-29% and 81-94% in children and 13-31% and 68-70% in adults. Before PCV introduction the most prevalent serotypes (≥5%) were 14, 19A, 1, 23F, 19F, 6B, 18C, 7F, 9V in children and 14, 3, 7F, 4, 5, 1, 9V, 19A, 23F, 6B in adults. After PCV7 introduction the most prevalent serotypes were 19A, 7F, 14, 3, 1, 6A, 18C, 5 in children and 7F, 19A, 1, 3, 15, 14, 4, in adults. The distributions differed across the countries.