We carried out improvement activities for three times for the patients who were inserted with central venous catheter from April 2011 to October 2012. First (2011.04-2011.07), 1) Prevention protocol review about BSI and sharing the protocol with relevant department, 2) SMS feedback to medical team about checklists and results with Maximum sterile barrier precaution, 3) Weekly experts (ID physician and IC nurse) rounding to ICU and CCU, and checking condition of central venous catheter. Second (2012.05), 1) Continuing previous improvement activity, 2) Sharing the protocol for sampling method of blood culture with relevant department, 3) Writing the name who inserted central venous catheter at the insertion site. Third (2012.08-2012.10), 1) Notifying above protocols periodically, 2) Changing antiseptic from betadine to 2% alcoholic chlorhexidine gluconate solution since July 2012 when the commercial product was available.