From 2003 to 2012, 590 episodes of CRB were detected in 578 non-ICU patients; 285 in medical wards and 305 in surgical wards. Mean age was 64y (SD 14y) and 37% were females. Mortality was 16.1%. Among all episodes of CRB, 332 (56%) were caused by central venous catheter (19% subclavian, 17% jugular, 12% femoral, 8% peripheral inserted central catheter) and 258 (44%) by peripheral venous catheter. Gram positive cocii caused 72% of episodes, gram negative bacilli 28% and fungi 1%. Among them, S.aureus was identified in 235 episodes (40%), coagulase negative in 174 (29%), enterococci in 23 (4%), P.aeruginosa in 33 (6%) and Candida spp in 7 episodes (1%). Independent risk factors associated to mortality in multivariate analysis were: age older than 65y (OR: 2.0;95% CI:1.2-3.2), hospitalization in medical wards (OR:1.6;95CI:1.0-2.6) and S.aureus (OR:3.1;95%CI:1.9-5.0), while type of catheter and place of insertion were not associated.