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P084: Analysis of therapeutic efficacies of amodiaquine-arstesunate and artemether-lumefantrine for treatment of uncomplicated falciparum malaria in Burkina Faso five years after their implementation
Antimicrobial Resistance and Infection Control volume 2, Article number: P84 (2013)
Introduction
Since 2005, Burkina Faso adopted artesunate plus amodiaquine (ASAQ) and artemether-lumefantrine (AL) as first-line treatment for uncomplicated malaria. Despite improvement in that treatment, malaria remains the first cause of morbidity and mortality in the country.
Objectives
This study aimed to analyze the therapeutic efficacies of ASAQ and AL for the treatment of uncomplicated falciparum malaria in Burkina Faso five years after their adoption.
Methods
Per-protocol individual data from four randomized clinical trials supported by IRSS-DRO Bobo Dioulasso in 2006, 2008, 2009 and 2010, including 1076 patients with uncomplicated P. falciparum malaria, treated with the recommended regimen of AL or ASAQ, were analyzed according to WWARN analytical methods. Patients benefited from a clinical and biological 28-day follow-up and performed on days 2, 3, 7, 14 and 28 to evaluate clinical and parasitological outcomes. Treatment failures have been corrected by PCR.
Results
Using WWARN analytical methods, the unadjusted Kaplan-Meier survival estimates are 76.4% (95% CI (72.5-79.8)) in the AL group (N=544) and 87.1% (95% CI (83.9-89.7)) in the ASAQ group (N=532). After PCR correction, AL was less efficacious than ASAQ respectively 95.8% (95% CI (93.6-97.3)) vs 98.2% (95% CI (96.6-99.1)); OR=0,486 (95% CI (0.217-1.089). There was no significant correlation between the occurrence of recrudescent at day 28 end-point and study year in two groups (coefficient<0).
Conclusion
AL and ASAQ remain effective as treatment for uncomplicated malaria according to WHO recommendations, though AL was inferior in preventing recrudescent for 28-day follow-up.
Disclosure of interest
None declared.
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Correspondence to FW Nikiema.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Nikiema, F., Zongo, I., Some, F. et al. P084: Analysis of therapeutic efficacies of amodiaquine-arstesunate and artemether-lumefantrine for treatment of uncomplicated falciparum malaria in Burkina Faso five years after their implementation. Antimicrob Resist Infect Control 2, P84 (2013). https://doi.org/10.1186/2047-2994-2-S1-P84
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Keywords
- Clinical Trial
- Infectious Disease
- Malaria
- Treatment Failure
- Therapeutic Efficacy
