323 BMR were collected during the study period. The average age was 32 years [4 days, 95 years] and the sex ratio was 1.70. ESBL-producing Enterobacteriaceae (80%) followed by Acinetobacter multiresistant respectively (11%), ticarcillin-resistant Pseudomonas aeruginosa (4%) and methicillin-resistant Staphylococcus aureus (4%) were the most common isolates. ESBLs were as follows: 55% Klebsiella, E. coli 32% 11% Enterobacter, and others 2%. Blood cultures were the most common samples (40%), followed respectively by urinary tract infections (37%) and abscesses (16%). The pediatrics department was most affected (45%), followed respectively by the Internal Medicine and Resuscitation (each 23%) and Surgery (9%). A catheter was present in 91% of patients with sepsis and 66% of ESBL infections ESBL-producing Enterobacteriaceae were considered nosocomial.