Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition

Table 1 Variables associated with methicillin-resistant Staphylococcus aureus acquisition before and after accounting for confounding by indication

Variable	Odds ratio (95% CI), P Value
Variable	Before accounting for confounding by indication^a	After accounting for confounding by indication
Methicillin-sensitive S. aureus carrier	0.5 (0.3, 1.0), 0.03	0.4 (0.2, 0.8), 0.01
Intubation	4.7 (1.8, 12.3), 0.002	5.3 (2.0, 14.4), 0.001
Fluoroquinolone	1.9 (1.2, 3.0), 0.01	-
Aminoglycoside	-	0.3 (0.1, 0.7), 0.003
Days from ICU admission to negative swab	< .0001	< .0001
1	1.0, reference	1.0, reference
2	2.0 (1.2, 3.3)	2.2 (1.3, 3.7)
≥ 3	15.6 (8.4, 29.0)	19.6 (10.4, 37.1)
Chronic liver disease	-	4.1 (1.2, 13.6), 0.02

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