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Prevalence of colonisation with third generation cephalosporin-resistant enterobacteriacae (3GCREB) on admission - a cross-sectional study in 6 university hospitals


This admission prevalence survey is part of the multicenter study ATHOS (antibiotic therapy optimisation study). ATHOS aims at collecting prevalence and incidence data for nosocomial carriage of multi-drug resistant organisms (MDROs) and to intervene in the inpatient and outpatient setting.


The aim of this admission prevalence survey was to assess the rectal carriage of third generation cephalosporin-resistant enterobacteria (3GCREB) in patients on hospital admission and to perform risk factor analyses for 3GCREB carriage.


In 2014, we recruited adult patients within 72 h of admission to non-intensive care units in six German university hospitals. We obtained rectal swabs that were screened for 3GCREB. Each patient was asked to answer a short questionnaire on potential risk factors for colonisation with MDROs. Univariable and multivariable risk factor analyses were performed on preliminary data to identify those factors that were associated with 3GCREB prevalence.


Of the 4372 patients included, 423 patients were 3GCREB carriers (admission prevalence of 9.7%). Most isolates were Escherichia coli (76.8%). Surprisingly, 41.9% of all 3GCREB isolates were additionally resistant to fluoroquinolones. Only two patients (<0.1%) were colonised with carbapenemase-producing enterobacteria. Multivariable analysis associated the following risk factors with 3GCREB colonisation: centre, previous MDRO colonisation (OR = 2.16, p<0.001), antibiotic use (OR=2.08, p<0.001), travel abroad (OR=1.26, p=0.033) and management of gastroesophageal reflux disease (GERD) (OR=1.1, p=0.047).


To our knowledge, this is one of the largest admission prevalence surveys of 3GCREB in Germany. Interestingly, medical management of GERD and the specific centres to which the patients where admitted proved to be additional risk factors for 3GCREB colonisation on hospital admission. Whether information present on admission will be useful to improve prediction of nosocomial colonisation and infection as well as target infection control measures and therapy needs to be determined.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Rohde, A., Zweigner, J., Wiese-Posselt, M. et al. Prevalence of colonisation with third generation cephalosporin-resistant enterobacteriacae (3GCREB) on admission - a cross-sectional study in 6 university hospitals. Antimicrob Resist Infect Control 4 (Suppl 1), O43 (2015).

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