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  • Open Access

Clinical effectiveness of mupirocin for preventing S. aureus infections in non-surgical settings: a meta-analysis

  • R Nair1,
  • E Perencevich2,
  • A Blevins3,
  • M Goto2,
  • R Nelson4 and
  • ML Schweizer2
Antimicrobial Resistance and Infection Control20154(Suppl 1):O5

https://doi.org/10.1186/2047-2994-4-S1-O5

Published: 16 June 2015

Keywords

Peritoneal DialysisHealthcare SettingMupirocinExit SiteCrude Odds Ratio

Introduction

A protective effect of mupirocin has been seen among surgical, nonsurgical and dialysis patients. Our aim is to summarize evidence for mupirocin decolonization for prevention of S. aureus infections in non-surgical healthcare settings.

Objectives

To identify the optimal setting and patient population to implement mupirocin decolonization for prevention of S. aureus infections using meta-analytic methods.

Methods

We conducted systematic searches in PubMed, Cochrane Library Databases, Scopus, Web of Science, and ClinicalTrials.gov to identify papers published until 2013 on effectiveness of mupirocin in healthcare settings. Two investigators independently abstracted data with a pilot-tested form. Risk of bias was assessed using the Cochrane tool. The crude odds ratios were pooled (cpOR) using a random-effects model. Heterogeneity was evaluated using the Woolf’s test for homogeneity and I 2 statistics.

Results

Of the 12,644 studies identified, 8 randomized controlled trials and 19 quasi-experimental studies met the study inclusion criteria. Mupirocin was observed to reduce the odds of S. aureus infections by 70% (cpOR=0.30, 95% CI 0.23, 0.39) and 60% (cpOR=0.40, 95% CI 0.27, 0.62) in both dialysis and non-dialysis settings, respectively. Nevertheless, there was highly significant (p=0.0009) and moderate heterogeneity (I 2 =46%) among studies. Studies were homogeneous (p>0.1) when stratified analyses were performed by specific clinical settings. Among the 6 studies that took place in adult intensive care units (ICUs), mupirocin decolonization was associated with a 56% reduction in the odds of S. aureus infection (cpOR=0.44, 95% CI 0.26, 0.73). There was also a protective effect of mupirocin against S. aureus exit site infections among patients undergoing peritoneal dialysis (cpOR=0.23, 95% CI 0.15, 0.36) and against bacteremia among hemodialysis patients (cpOR=0.15, 95%CI 0.06, 0.36).

Conclusion

Mupirocin decolonization is protective against S. aureus infections among both dialysis and adult ICU patient populations. Future studies should target other patient settings such as long-term care facilities.

Disclosure of interest

None declared.

Authors’ Affiliations

(1)
Epidemiology, University of Iowa, Iowa City, USA
(2)
Internal Medicine, University of Iowa, Iowa City, USA
(3)
Library Sciences, University of Iowa, Iowa City, USA
(4)
Internal Medicine, University of Utah, Salt Lake City, USA

Copyright

© Nair et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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