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  • Oral presentation
  • Open Access

Cost-effectiveness of hand hygiene promotion for MRSA blood stream infection in ICU settings

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Antimicrobial Resistance and Infection Control20154 (Suppl 1) :O50

  • Published:


  • Bloodstream Infection
  • Hand Hygiene
  • Decision Analytic Model
  • Transmission Dynamic
  • Blood Stream Infection


Multimodal interventions are effective in increasing hand hygiene compliance amongst healthcare workers, but it is not known whether such interventions are cost-effective outside high-income countries.


To determine whether reductions in Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSI) alone would make hand hygiene interventions cost-effective in intensive care units (ICUs) in a middle-income country using a model-based framework.


Transmission dynamic and decision analytic models were combined to determine the expected impact of hand hygiene interventions on MRSA-BSI incidence and evaluate their cost-effectiveness. Epidemiological and economic parameters were derived using data from a tertiary hospital in North-east Thailand. Sensitivity analyses were performed with different values for MRSA transmissibility and colonization prevalence on admission.


Interventions increasing hand hygiene compliance from a 10% baseline to ≥20% are likely to be cost-effective solely through reduced MRSA-BSI. Increasing compliance from 10% to 40% was estimated to cost $US 89·1 per bed-year with 4·07 QALYs gained per 10,000 bed-days in the paediatric ICU (PICU) and $US 63·3 per bed-year with 4·03 QALYs gained per 10,000 bed-days in the adult ICU. If baseline compliance is not greater than 20%, the intervention is always cost-effective even with only a 10% compliance improvement.


Effective multimodal hand hygiene interventions are likely to be cost-effective in ICU settings in typical middle-income countries where baseline compliance is low due to preventing MRSA-BSI alone. Where compliance is higher, the cost-effectiveness of interventions to improve it further will depend on the impact on HAIs other than MRSA-BSI.

Disclosure of interest

None declared.

Authors’ Affiliations

Mahidol-Oxford Research Unit, Bangkok, Thailand
Pediatrics, Sappasithiprasong Hospital, Ubon Ratchatani, Thailand
School of Public Health, Queensland University of Technology, Brisbane, Australia