- Poster presentation
- Open Access
Urinary tract infections caused by Pseudomonas aeruginos among children in southern Poland
Antimicrobial Resistance and Infection Control volume 4, Article number: P262 (2015)
Urinary tract infections (UTIs) are an important cause of morbidity and mortality during the first 2 years of life. Knowledge of the antimicrobial resistance patterns may help clinicians choosing the empirical treatment.
The aim was to analyze the resistance and virulence of PAR causing UTIs among children in Southern Poland.
PCR-screening for lasB, exoS, pilA, aprA and pilB and antimicrobial-susceptibility were performed. MDR was non-susceptible to one antimicrobial in ≥3 antimicrobial classes. Extensively-drug resistant (XDR) was susceptible to ≤2 antimicrobial classes. PCR-screening for VIM, IMP and KPC was performed.
Median age (Q1;Q3) of the population (25 children) was 1.5 year (1;3). The most prevalent virulence gene was exoS (92.3%), modulating bacterial phagocytosis and invasion into cells. LasB gene (degrades of human competent molecules), was present among 80.8% of the isolates. AprA (aeruginolysin that degrades biologically important proteins) was present in 61.5%. PilB gene was not detected. Of the isolates, 92% were susceptible to gentamycin, tobramycin or cefepime, 85% to amikacin. A large number of isolates were resistant to meropenem (38.5%) or imipenem (19.2%). All were susceptible to colistin. Two isolates were XDR, 1 was MBL-positive. No KPC, IMP, VIM were found.
Empirical selection of the antibiotics should be based on the knowledge of local antimicrobial susceptibilities of pathogens rather than on universal guidelines to maximize the benefit for patients and minimize the risk of developing drug-resistance. In this study, gentamycin and beta-lactams were shown to be the most appropriate for UTIs empiric therapy among children. Supported by 2012/05/N/NZ7/00786
Disclosure of interest
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Pobiega, M., Maciąg, J., Chmielarczyk, A. et al. Urinary tract infections caused by Pseudomonas aeruginos among children in southern Poland. Antimicrob Resist Infect Control 4 (Suppl 1), P262 (2015). https://doi.org/10.1186/2047-2994-4-S1-P262
- Urinary Tract Infection