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Complex application of bacteriophages as a method of healthcare-associated infections control

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Antimicrobial Resistance and Infection Control20154 (Suppl 1) :P46

  • Published:


  • Intensive Care Unit
  • Infection Control
  • Specialized Department
  • Healthcare Setting
  • Considerable Progress


Prevention of healthcare-associated infections is one of the global problems in modern period of healthcare system development.


Prophylaxis of HAI in Russia.


Epidemiological, statistical.


Over the past 50 years in Russia, considerable progress in theoretical evidence and practical application of bacteriophages to treat and prevent healthcare-associated infections has accumulated. The efficient use of bacteriophages in epidemic outbreaks of healthcare-associated infections has been documented in numerous representative studies of different epidemiological centers in Russia: Kemerovo, St. Petersburg, Moscow, Nizhny Novgorod, Ufa and others.

One of the important areas of application is the use of bacteriophages for the decontamination of inanimate objects and surfaces in healthcare settings. Disinfection by using bacteriophages is the most suitable in epidemiologically relevant specialized departments such as intensive care units, burn units, etc. Drugs containing phages adapted to circulating bacterial strains will be more efficient compare to their non-adapted counterparts.


Numerous randomized controlled trials revealed different efficacy regarding the usage of bacteriophages in the environment. The greatest effect was obtained using Pseudomonas bacteriophage: complete elimination of the pathogen was achieved within 24 hours after a single application, and there were no new cases of healthcare-associated Pseudomonas infections. This is also the case for Salmonella bacteriophage effect (15-fold incidence reduction).

Disclosure of interest

None declared.

Authors’ Affiliations

Research Institute for Complex Issues of Cardiovascular Diseases, Russian Federation
State Budget Educational Institution of Higher Professional Education “Kemerovo State Medical University”, Kemerovo, Russian Federation
State Budget Educational Institution of Higher Professional Education «I.I. Mechnikov’s North Western State Medical University», Saint Petersburg, Russian Federation
State Budget Educational Institution of Higher Professional Education “I.M. Sechenov’s First Moscow State Medical University”, Moscow, Russian Federation
Federal Budget Scientific Institution “Scientific Research Disinfectology Institute” of Federal Service for Surveillance on Consumer Rights Protection and Human Well-being, Moscow, Russian Federation


© Brusina et al; licensee BioMed Central Ltd. 2015

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