Skip to main content

Complex application of bacteriophages as a method of healthcare-associated infections control

Introduction

Prevention of healthcare-associated infections is one of the global problems in modern period of healthcare system development.

Objectives

Prophylaxis of HAI in Russia.

Methods

Epidemiological, statistical.

Results

Over the past 50 years in Russia, considerable progress in theoretical evidence and practical application of bacteriophages to treat and prevent healthcare-associated infections has accumulated. The efficient use of bacteriophages in epidemic outbreaks of healthcare-associated infections has been documented in numerous representative studies of different epidemiological centers in Russia: Kemerovo, St. Petersburg, Moscow, Nizhny Novgorod, Ufa and others.

One of the important areas of application is the use of bacteriophages for the decontamination of inanimate objects and surfaces in healthcare settings. Disinfection by using bacteriophages is the most suitable in epidemiologically relevant specialized departments such as intensive care units, burn units, etc. Drugs containing phages adapted to circulating bacterial strains will be more efficient compare to their non-adapted counterparts.

Conclusion

Numerous randomized controlled trials revealed different efficacy regarding the usage of bacteriophages in the environment. The greatest effect was obtained using Pseudomonas bacteriophage: complete elimination of the pathogen was achieved within 24 hours after a single application, and there were no new cases of healthcare-associated Pseudomonas infections. This is also the case for Salmonella bacteriophage effect (15-fold incidence reduction).

Disclosure of interest

None declared.

Author information

Affiliations

Authors

Corresponding author

Correspondence to V Akimkin.

Rights and permissions

Open Access  This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.

The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Brusina, E., Drozdova, O., Zueva, L. et al. Complex application of bacteriophages as a method of healthcare-associated infections control. Antimicrob Resist Infect Control 4, P46 (2015). https://doi.org/10.1186/2047-2994-4-S1-P46

Download citation

Keywords

  • Intensive Care Unit
  • Infection Control
  • Specialized Department
  • Healthcare Setting
  • Considerable Progress