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Table 3 Patient characteristics, microbial characteristics, or treatments associated with strain type (N = 65)

From: Association between microbial characteristics and poor outcomes among patients with methicillin-resistant Staphylococcus aureus pneumonia: a retrospective cohort study

Characteristics USA100 N = 36 USA300 N = 29 P-value
Patient characteristics
 Gender: Female 16 (44 %) 9 (31 %) 0.269
 Age ≥55 years 24 (67 %) 11 (38 %) 0.021
 Hospital admission within previous 12 months 21 (58 %) 11 (38 %) 0.102
 Hospital-acquired infection 10 (28 %) 12 (41 %) 0.249
 Previous MRSA infection or colonization 8 (22 %) 5 (17 %) 0.618
 Positive influenza test 1 (3 %) 2 (7 %) 0.582
 Post-infection length of stay: median (IQR), in daysa 6 (2–18) 12 (4–24) 0.232
 Charlson Comorbidity Index score: median (IQR) 2 (1–3) 2 (0–4) 0.778
 30-day mortalityb 11 (31 %) 4 (14 %) 0.111
Antimicrobial prescribed
 Linezolid 11 (31 %) 2 (7 %) 0.018
 Vancomycin 33 (92 %) 29 (100 %) 0.247
Microbial characteristics
agr dysfunction 8 (22 %) 4 (14 %) 0.384
 Toxic shock syndrome toxin-1 1 (3 %) 0 (0 %) 1.000
 hVISA 1 (3 %) 0 (0 %) 1.000
 Arginine catabolic mobile element 1 (3 %) 23 (79 %) <0.001
 Panton-Valentine leukocidin 0 (0 %) 26 (90 %) <0.001
 SCCmec
  Type II 35 (97 %) 4 (14 %) <0.001
  Type IV 0 (0 %) 25 (86 %) <0.001
  1. IQR interquartile range, SCCmec staphylococcal cassette chromosome mec, agr accessory gene regulator, PFGE pulsed-field gel electrophoresis, hVISA heterogeneous vancomycin-intermediate S. aureus
  2. aDefined as the day the first respiratory or blood culture that grew MRSA was collected until the day the patient was either discharged from the hospital or died
  3. bDefined as death occurring within the first 30 days after the day when the first respiratory or blood culture that grew MRSA was obtained