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Table 1 Univariate analysis of 7 days mortality in patients with extended-spectrum beta-lactamase (ESBL)-positive or -negative E. coli and K. pneumoniae bloodstream infection (during hospitalization)

From: E. coli bacteremia in comparison to K. pneumoniae bacteremia: influence of pathogen species and ESBL production on 7-day mortality

Parameter Survived until 7 days after BSI Died within 7 days after BSI 7-days Mortality P-value Survived/ discharged after BSI Died in-hospital after BSI In-hospital Mortality P-value
Number (%) Number (%) Number (%) Number (%)
Patients 1.690 (100 %) 161 (100 %) 8.7 %   1485 (100 %) 366 (100 %) 19.8 %  
K. pneumoniae 319 (18.9 %) 33 (20.5 %) 9.4 % 0.616 264 (17.8 %) 88 (24.0 %) 25.0 % 0.006
E. coli 1371 (81.1 %) 128 (79.5 %) 8.5 % 1221 (82.2 %) 278 (76.0 %) 18.5 %
ESBL-positive 219 (13.0 %) 25 (15.5 %) 10.2 % 0.357 183 (12.3 %) 61 (16.7 %) 25.0 % 0.028
Hospital mortality 205 (12.1 %) 161 (100.0 %) 44.0 % <0.001 - 366 (100.0 %) 100.0 % n.a.
Polymicrobial 198 (11.7 %) 27 (16.8 %) 12.0 % 0.061* 160 (10.8 %) 65 (17.8 %) 28.9 % <0.001*
Age (years)a 65 (52–73)a 67 (57–76)a n.a. 0.019* 65 (52–73)a 66 (54–74)a n.a. 0.134*
Male 929 (55.0 %) 93 (57.8 %) 9.1 % 0.496 799 (53.8 %) 223 (60.9 %) 21.8 % 0.014
Hospital onset 746 (44.1 %) 84 (52.2 %) 10.1 % 0.050* 612 (41.2 %) 218 (59.6 %) 26.3 % <0.001*
ICU stay 1.072 (63.4 %) 125 (77.6 %) 10.4 % <0.001* 896 (60.3 %) 301 (82.2 %) 25.1 % <0.001*
Charlson comorbidity indexa 5 (3–8)a 8 (6–10)a n.a. <0.001 5 (3–8)a 8 (6–10)a n.a. <0.001
Heart disease 275 (16.3 %) 47 (29.2 %) 14.6 % <0.001* 215 (14.5 %) 107 (29.2 %) 33.2 % <0.001*
Cerebrovascular disease 243 (14.4 %) 31 (19.3 %) 11.3 % 0.096* 202 (13.6 %) 72 (19.7 %) 26.3 % 0.003*
Neurologic disease 123 (7.3 %) 11 (6.8 %) 8.2 % 0.835 112 (7.5 %) 22 (6.0 %) 16.4 % 0.311
Lung disease 218 (12.9 %) 24 (14.9 %) 9.9 % 0.470 181 (12.2 %) 61 (16.7 %) 25.2 % 0.023
Gastrointestinal disease 53 (3.1 %) 12 (7.5 %) 18.5 % 0.004* 36 (2.4 %) 29 (7.9 %) 44.6 % <0.001*
Rheumatic disease 50 (3.0 %) 2 (1.2 %) 3.8 % 0.208 44 (3.0 %) 8 (2.2 %) 15.4 % 0.420
Liver disease 258 (15.3 %) 53 (32.9 %) 17.0 % <0.001* 180 (12.1 %) 131 (35.8 %) 42.1 % <0.001*
Diabetes 422 (25.0 %) 48 (29.8 %) 10.2 % 0.177 366 (24.6 %) 104 (28.4 %) 22.1 % 0.138
Renal disease 711 (42.1 %) 115 (71.4 %) 13.9 % <0.001* 565 (38.0 %) 261 (71.3 %) 31.6 % <0.001*
Cancer/immunological disease 672 (39.8 %) 75 (46.6 %) 10.0 % 0.092* 571 (38.5 %) 176 (48.1 %) 23.6 % 0.001*
  1. BSI bloodstream infection, LOS length of stay, N.a. not applicable
  2. * Included in the multivariable Cox-proportional hazard regression
  3. a Continuous parameter displayed as median (interquartile range)
  4. P-values <0.05 were considered statistically significant
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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