Daptomycin-induced eosinophilic pneumonia - a systematic review

Table 1 Criteria for inclusion as definite, probably, possible, and unlikely cases of daptomycin-induced eosinophilic pneumonia [1, 2]

Definite	Probable	Possible	Unlikely
Concurrent exposure to daptomycin	Concurrent exposure to daptomycin	Concurrent exposure to daptomycin	All other cases that did not meet criteria
Dyspnea with increased oxygen requirement or requiring mechanical ventilation	Dyspnea with increased oxygen requirement or requiring mechanical ventilation	New infiltrates on CXR or CT
New infiltrates on CXR or CT	New infiltrates on chest x-ray or CT	Clinical improvement following daptomycin withdrawal OR the patient died
BAL with > 25% eosinophils	BAL with ≤ 25% eosinophils OR peripheral eosinophilia
Clinical improvement following daptomycin withdrawal	Clinical improvement following daptomycin withdrawal
Fever

Adapted from references 1 and 2
Abbreviation: BAL bronchoalveolar lavage; CT computed tomography; CXR chest x-ray

ISSN: 2047-2994