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Table 1 Summary MIC data for nine antimicrobials against 105 Thai C. difficile isolates

From: Antimicrobial susceptibility of Clostridium difficile isolated in Thailand

Antimicrobiala MIC range (mg/L) MIC50 (mg/L) MIC90 (mg/L) Clinical breakpoints [11] Susceptible Intermediate Resistant
S I R N % N % N %
FDX 0.004–0.25 0.06 0.25
VAN 0.06–2 1 2 ≤2 >2 105 100.0 0 0.0 0 0.0
MTZ 0.015–0.5 0.25 0.25 ≤2 >2 105 100.0 0 0.0 0 0.0
RFX 0.008–>16 0.015 >16
CLI 0.015–>32 8 >32 ≤2 4 ≥8 17 16.2 11 10.5 77 73.3
ERY 0.12–>256 2 >256 >8 37 35.2
AMC 0.03–2 0.5 1 ≤4 8 ≥16 105 100.0 0 0.0 0 0.0
MXF 0.12–32 2 16 ≤2 4 ≥8 82 78.1 1 1.0 22 21.0
MEM 0.25–4 2 4 ≤4 8 ≥16 105 100.0 0 0.0 0 0.0
  1. a FDX fidaxomicin, VAN vancomycin, MTZ metronidazole, RFX rifaximin, CLI clindamycin, ERY erythromycin, AMC amoxicillin/clavulanate, MXF moxifloxacin, MEM meropenem