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Table 1 Patient characteristics and outcomes according to carbapenem-nonsusceptible A. baumannii-calcoaceticus complex status

From: Endemic carbapenem-nonsusceptible Acinetobacter baumannii-calcoaceticus complex in intensive care units of the national referral hospital in Jakarta, Indonesia

 

Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex positive on admission

Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex acquired during ICU stay

Carbapenem-nonsusceptible A. baumannii-calcoaceticus complex negative

p value

n = 69

(n = 89)

n = 254

Age (years), median (IQR)

47 (33–60)

48 (35.3–57)

46 (32–58)

0.700

Gender (%)

   

0.535

 Male

35 (50.7)

42 (47.2)

137 (53.9)

 

 Female

34 (49.3)

47 (52.8)

117 (46.1)

 

Underlying diseases (%)

Cardiovascular

   

0.024

 Yes

9 (13.0)

3 (3.4)

13 (5.1)

 

 No

60 (87.0)

86 (96.6)

241 (94.9)

 

Cerebrovascular

   

0.001

 Yes

3 (4.3)

14 (15.7)

12 (4.7)

 

 No

66 (95.7)

75 (84.3)

242 (95.3)

 

Chronic kidney disease

   

0.915

 Yes

5 (7.2)

8 (9.0)

20 (7.9)

 

 No

64 (92.8)

81 (91.0)

234 (92.1)

 

Diabetes mellitus

   

0.334

 Yes

20 (29.0)

20 (22.5)

78 (30.7)

 

 No

49 (71.0)

69 (77.5)

176 (69.3)

 

Malignancy

   

0.740

 Yes

29 (42.0)

37 (41.6)

116 (45.7)

 

 No

40 (58.0)

52 (58.4)

138 (54.3)

 

Indication for ICU admission (%)

   

0.002

 Medical

32 (46.4)

38 (42.7)

70 (27.6)

 

 Surgical

37 (53.6)

51 (57.3)

184 (72.4)

 

Referral from (%)

   

0.900

 Other ward this hospital

38 (55.1)

48 (53.9)

136 (53.5)

 

 Other hospital

14 (20.3)

14 (15.7)

49 (19.3)

 

 Directly from Emergency Unit

17 (24.6)

27 (30.3)

69 (27.2)

 

Antibiotic exposure (pre-ICU admission)

 Any antibiotic (%)

58 (84.1)

73 (82.0)

180 (70.9)

0.021

 Carbapenem (%)

24 (34.8)

22 (24.7)

33 (13.0)

<0.01

SIRS Score, (%)

   

0.916

 Score ≥ 2

64 (92.8)

81 (91.0)

232 (91.3)

 

 Score < 2

5 (7.2)

8 (9.0)

22 (8.7)

 

qSOFA Score, (%)

   

0.089

 Score ≥ 2

51 (73.9)

78 (87.6)

205 (80.7)

 

 Score < 2

18 (26.1)

11 (12.4)

49 (19.3)

 

Procedures (during ICU admission)

 Mechanical ventilation (%)

63 (91.3)

88 (98.9)

220 (86.6)

0.004

 Mechanical ventilation (days) median(IQR)

5 (2–8)

8 (4–16)

3 (1–6)

 

  ≥ 5 days (%)

36 (52.2)

63 (70.8)

83 (2.7)

<0.01

  < 5 days (%)

33 (47.8)

26 (29.2)

171 (67.3)

 

 Central venous catheter (%)

66 (95.7)

85 (95.5)

212 (83.5)

<0.01

 Central venous catheter (days) median(IQR)

6 (3–9)

10 (5–17)

4 (2–7)

 

  ≥ 5 days (%)

41 (59.4)

71 (79.8)

111 (3.7)

<0.01

  < 5 days (%)

28 (40.6)

18 (20.2)

143 (56.3)

 

 Urine catheter

69 (100)

89 (100)

254 (100)

N/A

 Urine catheter (days) median (IQR)

6 (3–10)

10 (6–18)

5 (3–7)

 

  ≥ 5 days (%)

26 (37.7)

13 (14.6)

122 (48.0)

<0.01

  < 5 days (%)

43 (62.3)

76 (85.4)

132 (52.0)

 

Antibiotic therapy (during ICU admission)

 Any antibiotic (%)

68 (98.6)

89 (100)

249 (98.0)

0.411

 Carbapenem (%)

42 (60.9)

62 (69.7)

95 (37.4)

<0.01

Outcomes

 Length of stay (days), median (IQR)

5 (3–9)

11 (5–18)

4 (3–7)

<0.01

 Death

22 (31.9)

38 (42.7)

59 (23.2)

0.002

  1. Abbreviations: ICU, Intensive Care Unit; IQR, Interquartile range; qSOFA, quick Sepsis-related Organ Failure Assessment; SIRS, Systemic Inflammatory Response Syndrome
  2. Significance was calculated using Oneway ANOVA and Pearson Chi Square
  3. A p-value less than 0.01 was considered statistically significant