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Table 4 Antimicrobial susceptibility among Gram-positive isolates including multi-drug resistance(MDR) strains from blood specimens collected between 2012 and 2016

From: Antimicrobial susceptibility among gram-positive and gram-negative blood-borne pathogens collected between 2012-2016 as part of the Tigecycline Evaluation and Surveillance Trial

  Africa Asia Europe North America Latin America Global Global
S% S% S% S% S% MIC90(mg/L) MIC range(mg/L) S% R% MIC90(mg/L) MIC range(mg/L) S% R%
  S.aureus S.aureus, all isolates MRSA
N = 43 N = 298 N = 2008 N = 814 N = 161 N = 3324 N = 1096
Levofloxacin 65.1 57.4 69.3 67.3 77.0 16 0.06–64 68.1 30.2 64 0.06–64 21.9 75.6
Linezolid 100.0 100.0 100.0 100.0 100.0 2 0.5–4 100.0 0.0 2 0.5–4 100.0 0.0
Minocycline 83.7 97.3 99.5 98.3 100.0 0.25 0.25–16 98.8 0.1 0.5 0.25–16 97.5 0.1
Penicillin 2.3 6.0 15.9 16.6 8.1 16 0.06–16 14.7 85.4 16 0.12–16 0.1 99.9
Tigecycline 100 99.7 100.0 100.0 100.0 0.12 0.008–1 99.9 0.0 0.25 0.015–1 99.9 0.0
Vancomycin 100.0 100.0 100.0 100.0 100.0 1 0.12–2 100.0 0.0 1 0.12–2 100.0 0.0
  E.faecalis E.faecalis, all isolates VR E.faecalis
N = 26 N = 99 N = 910 N = 406 N = 86 N = 1527 N = 22
Ampicillin 100.0 96.0 98.9 99.8 96.5 1 0.06–32 98.8 1.2 32 0.5–32 86.4 13.6
Levofloxacin 69.2 70.7 68.6 73.4 81.4 64 0.06–64 70.7 28.5 64 0.5–64 13.6 86.4
Linezolid 100.0 97.0 100.0 100.0 97.7 2 0.5–8 99.7 0.1 2 0.5–2 100.0 0.0
Minocycline 30.8 35.4 36.8 35.2 38.4 8 0.25–16 36.3 6.3 8 0.25–8 27.3 0.0
Penicillin 100.0 95.0 98.8 99.8 96.5 4 0.06–16 98.7 1.3 16 2–16 86.4 13.6
Tigecycline 100.0 100.0 99.9 100.0 100.0 0.12 0.008–0.5 100.0 0.0 0.12 0.03–0.12 100.0 0.0
Vancomycin 96.2 98.0 99.0 96.6 98.8 2 0.12–64 98.2 1.4 64 32–64 0.0 100.0
  E.faecium E.faecium, all isolates VR E.faecium
N = 9 N = 89 N = 603 N = 268 N = 31 N = 1000 N = 276
Ampicillin 11.1 12.4 11.1 14.2 6.5 32 0.06–32 11.9 88.1 32 4–32 0.7 99.3
Levofloxacin 22.2 9.0 9.8 12.3 12.9 64 0.06–64 10.6 87.0 64 8–64 0.0 100.0
Linezolid 100.0 100.0 99.7 98.8 100.0 2 0.5–8 99.5 0.2 2 0.5–8 98.9 0.4
Minocycline 88.9 47.2 70.2 59.0 80.7 8 0.25–16 65.6 6.2 8 0.25–16 58.7 6.2
Penicillin 11.1 14.6 13.1 12.7 6.5 16 0.06–16 12.9 87.1 16 4–16 1.5 98.6
Tigecycline 100.0 100.0 99.5 98.9 100.0 0.12 0.008–1 99.4 0.0 0.12 0.008–1 98.9 0.0
Vancomycin 66.7 78.7 87.1 38.1 41.9 64 0.12–64 71.6 27.6 64 32–64 0.0 100.0
  S.pneumoniae S.pneumoniae, all isolates PR S.pneumoniae
N = 23 N = 66 N = 1248 N = 553 N = 93 N = 1983 N = 178
Amoxy/clav 91.3 95.5 98.0 96.2 93.6 1 0.03–16 97.1 1.1 8 0.03–16 68.5 11.8
Azithromycin 69.6 38.1 81.1 63.0 44.6 64 0.03–512 72.7 26.0 128 0.03–512 28.7 69.0
Ceftriaxone 100.0 94.0 98.7 99.0 98.9 0.5 0.03–8 98.6 0.1 2 0.03–8 86.0 1.1
Clarithromycin 69.6 39.7 80.9 63.0 69.6 128 0.015–128 73.9 26.0 128 0.015–128 30.5 69.0
Clindamycin 78.3 61.9 85.3 87.4 79.4 128 0.015–128 84.7 14.8 128 0.015–128 53.5 45.4
Erythromycin 69.6 39.7 80.8 63.6 69.6 64 0.015–128 74.0 25.8 128 0.015–128 29.9 69.0
Levofloxacin 100.0 98.5 99.6 99.6 98.9 1 0.06–16 99.6 0.4 1 0.12–16 99.4 0.6
Linezolid 100.0 100.0 100.0 100.0 100.0 1 0.5–2 100.0 0.0 1 0.5–2 100.0 0.0
Meropenem 81.0 60.6 89.7 87.0 86.0 0.5 0.12–8 87.8 7.1 1 0.12–8 3.4 70.8
Minocycline 73.9 37.9 77.5 83.7 69.9 4 0.25–16 77.5 16.8 8 0.25–16 46.1 45.0
Penicillin 69.6 34.9 70.4 69.8 55.9 1 0.06–16 68.3 9.0 4 2–16 0.0 100.0
Tigecycline 100.0 98.5 99.8 99.5 100.0 0.03 0.008–4 99.7 0.0 0.03 0.008–0.12 100.0 0.0
Vancomycin 100.0 100.0 100.0 100.0 100.0 0.5 0.12–1 100.0 0.0 0.5 0.12–1 100.0 0.0
  S.agalactiae  
N = 8 N = 64 N = 505 N = 373 N = 32 N = 982  
Ampicillin 100.0 100.0 100.0 100.0 100.0 0.12 0.06–0.25 100.0 0.0     
Ceftriaxone 100.0 100.0 100.0 100.0 100.0 0.12 0.03–0.5 100.0 0.0     
Levofloxacin 100.0 95.3 98.2 96.5 87.5 1 0.06–64 97.1 2.7     
Linezolid 100.0 100.0 100.0 100.0 100.0 1 0.5–2 100.0 0.0     
Meropenem 100.0 100.0 100.0 100.0 100.0 0.12 0.12–0.5 100.0 0.0     
Minocycline 12.5 20.3 17.8 22.0 50.0 16 0.25–16 20.6 62.7     
Penicillin 100.0 100.0 100.0 100.0 100.0 0.12 0.06–0.12 100.0 0.0     
Tigecycline 100.0 96.9 99.8 100.0 100.0 0.06 0.008–4 99.7 0.0     
Vancomycin 100.0 100.0 100.0 100.0 100.0 0.5 0.12–1 100.0 0.0     
  1. Abbreviations: S% percentage of susceptible isolates, R% percentage of resistant isolates, MIC minimum inhibitory concentration, Amoxy/clav Amoxicillin/clavulanic acid