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Table 1 Accordance of the package sizes of selected drugs with guidelines for sore throat I

From: Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections

Drug Package size ISKRAa Min No. of Packages Extra units IDSAb Min No. of Packages Extra units NICEc
Amoxicillin 16x500 mgd n/a 2x500 mg, 10 days 2 12 n/a
1x1000 mg, 10 days 2 12
20x500 mg n/a 2x500 mg, 10 days 1 0
1x1000 mg, 10 days 1 0
16x1000 mgd n/a 2x500 mg, 10 days 1 6
1x1000 mg, 10 days 1 6
20x1000 mge n/a 2x500 mg, 10 days n/a n/a
1x1000 mg, 10 days 1 10
Co-amoxiclav 10x1000 mg 2x1000 mg, 10 days 2 0 n/a n/a
12x1000 mgd 2x1000 mg, 10 days 2 4 n/a
14x1000 mgd 2x1000 mg, 10 days 2 8 n/a
16x1000 mg 2x1000 mg, 10 days 2 12 n/a
20x1000 mg 2x1000 mg, 10 days 1 0 n/a
21x1000 mg 2x1000 mg, 10 days 1 1 n/a
24x1000 mg 2x1000 mg, 10 days 1 4 n/a
30x1000 mg 2x1000 mg, 10 days 1 10 n/a
Azithromycin 6x125 mg 1x500 mg, 3 days 2 0 1x500 mg, 5 days 4 4 n/a
6x250 mgd 1x500 mg, 3 days 1 0 1x500 mg, 5 days 2 2
1x500 mg 1x500 mg, 3 days 3 0 1x500 mg, 5 days 5 0
2x500 mg 1x500 mg, 3 days 2 1 1x500 mg, 5 days 3 1
3x500 mgd 1x500 mg, 3 days 1 0 1x500 mg, 5 days 2 1
6x500 mg 1x500 mg, 3 days 1 3 1x500 mg, 5 days 1 1
12x500 mg 1x500 mg, 3 days 1 9 1x500 mg, 5 days 1 7
24x500 mg 1x500 mg, 3 days 1 21 1x500 mg, 5 days 1 19
1x1000 mgd 1x500 mg, 3 days n/a n/a 1x500 mg, 5 days n/a n/a
2x1000 mg 1x500 mg, 3 days n/a n/a 1x500 mg, 5 days n/a n/a
3x1000 mg 1x500 mg, 3 days n/a n/a 1x500 mg, 5 days n/a n/a
6x1000 mg 1x500 mg, 3 days n/a n/a 1x500 mg, 5 days n/a n/a
Cephalexin 16x500 mgd n/a 2x500 mg, 10 days 2 12 n/a
16x1000 mgd n/a 2x500 mg, 10 days n/a n/a
Clindamycin 16x150 mgd 3x300 mg, 10 days 4 4 3x300 mg, 10 days 4 4 n/a
16x300 mgd 3x300 mg, 10 days 2 2 3x300 mg, 10 days 2 2
16x600 mgd 3x300 mg, 10 days 1 1 3x300 mg, 10 days 1 1
32x600 mgd 3x300 mg, 10 days 1 17 3x300 mg, 10 days 1 17
  1. Co-amoxiclav – amoxicillin and clavulanic acid; n/a – not applicable; extra units of drugs are presented with reference to the original formulation
  2. aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on sore throat: diagnostic and therapeutic approach – Croatian national guidelines
  3. bClinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America
  4. cNational Institute for Health and Care Excellence (NICE) Sore throat (acute): antimicrobial prescribing
  5. dincluded in Croatian national reimbursement lists on 1st of August 2018
  6. eincluded in Croatian national reimbursement lists prior to 1st of August 2018 (from 29th of November 2012)