Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections

Rusic, Doris; Bozic, Josko; Bukic, Josipa; Seselja Perisin, Ana; Leskur, Dario; Modun, Darko; Tomic, Sinisa

doi:10.1186/s13756-019-0495-5

Antimicrobial Resistance & Infection Control

Table 1 Accordance of the package sizes of selected drugs with guidelines for sore throat I

From: Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections

Drug	Package size	ISKRA^a	Min No. of Packages	Extra units	IDSA^b	Min No. of Packages	Extra units	NICE^c
Amoxicillin	16x500 mg^d	n/a			2x500 mg, 10 days	2	12	n/a
	16x500 mg^d	n/a			1x1000 mg, 10 days	2	12
	20x500 mg	n/a			2x500 mg, 10 days	1	0
	20x500 mg	n/a			1x1000 mg, 10 days	1	0
	16x1000 mg^d	n/a			2x500 mg, 10 days	1	6
	16x1000 mg^d	n/a			1x1000 mg, 10 days	1	6
	20x1000 mg^e	n/a			2x500 mg, 10 days	n/a	n/a
	20x1000 mg^e	n/a			1x1000 mg, 10 days	1	10
Co-amoxiclav	10x1000 mg	2x1000 mg, 10 days	2	0	n/a			n/a
	12x1000 mg^d	2x1000 mg, 10 days	2	4	n/a
	14x1000 mg^d	2x1000 mg, 10 days	2	8	n/a
	16x1000 mg	2x1000 mg, 10 days	2	12	n/a
	20x1000 mg	2x1000 mg, 10 days	1	0	n/a
	21x1000 mg	2x1000 mg, 10 days	1	1	n/a
	24x1000 mg	2x1000 mg, 10 days	1	4	n/a
	30x1000 mg	2x1000 mg, 10 days	1	10	n/a
Azithromycin	6x125 mg	1x500 mg, 3 days	2	0	1x500 mg, 5 days	4	4	n/a
	6x250 mg^d	1x500 mg, 3 days	1	0	1x500 mg, 5 days	2	2
	1x500 mg	1x500 mg, 3 days	3	0	1x500 mg, 5 days	5	0
	2x500 mg	1x500 mg, 3 days	2	1	1x500 mg, 5 days	3	1
	3x500 mg^d	1x500 mg, 3 days	1	0	1x500 mg, 5 days	2	1
	6x500 mg	1x500 mg, 3 days	1	3	1x500 mg, 5 days	1	1
	12x500 mg	1x500 mg, 3 days	1	9	1x500 mg, 5 days	1	7
	24x500 mg	1x500 mg, 3 days	1	21	1x500 mg, 5 days	1	19
	1x1000 mg^d	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	2x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	3x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
	6x1000 mg	1x500 mg, 3 days	n/a	n/a	1x500 mg, 5 days	n/a	n/a
Cephalexin	16x500 mg^d	n/a			2x500 mg, 10 days	2	12	n/a
Cephalexin	16x1000 mg^d	n/a			2x500 mg, 10 days	n/a	n/a	n/a
Clindamycin	16x150 mg^d	3x300 mg, 10 days	4	4	3x300 mg, 10 days	4	4	n/a
	16x300 mg^d	3x300 mg, 10 days	2	2	3x300 mg, 10 days	2	2
	16x600 mg^d	3x300 mg, 10 days	1	1	3x300 mg, 10 days	1	1
	32x600 mg^d	3x300 mg, 10 days	1	17	3x300 mg, 10 days	1	17

Co-amoxiclav – amoxicillin and clavulanic acid; n/a – not applicable; extra units of drugs are presented with reference to the original formulation
^aThe Intersectoral Society for Antibiotic Resistance Control (ISKRA) guidelines on sore throat: diagnostic and therapeutic approach – Croatian national guidelines
^bClinical Practice Guideline for the Diagnosis and Management of Group A Streptococcal Pharyngitis: 2012 Update by the Infectious Diseases Society of America
^cNational Institute for Health and Care Excellence (NICE) Sore throat (acute): antimicrobial prescribing
^dincluded in Croatian national reimbursement lists on 1^st of August 2018
^eincluded in Croatian national reimbursement lists prior to 1^st of August 2018 (from 29^th of November 2012)

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ISSN: 2047-2994

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