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Table 2 Clinical characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection and antibiotics applied for its treatment

From: Epidemiological, clinical, and microbiological characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection in the Republic of Korea

Characteristics Total
(N=131)
Survivor
(N=69)
Non-survivor
(N=62)
P
Age ± SD (years) 59.6±18.9 57.8±18.5 61.6±19.2 0.23
Male 86 (66) 46 (67) 40 (65) 0.25
Transfer history 47 (36) 24 (35) 23 (37) 0.93
Acquisition of infection     0.08
Community 5 (4) 5 (7) 0 0.06
Healthcare-associated 15 (12) 8 (12) 7 (11) 0.96
Hospital-acquired 111 (85) 56 (81) 55 (89) 0.23
Comorbidity
Total 112 (86) 62 (90) 50 (81) 0.21
DM 37 (28) 16 (23) 21 (34) 0.25
Solid organ cancer 34 (26) 18 (26) 16 (26) 1.00
Hematology cancer 33 (25) 20 (29) 13 (21) 0.39
ESRD 21 (16) 11 (16) 10 (16) 1.00
Heart disease 15 (12) 7 (10) 8 (13) 0.83
Liver disease 13 (9) 7 (10) 6 (10) 1.00
Stroke 12 (9) 7 (10) 5 (8) 0.91
Immunosuppressive therapy state 6 (5) 2 (3) 4 (7) 0.58
COPD 2 (2) 0 2 (3) 0.43
Charlson comorbidity index 4.7±3.0 4.4±2.8 5.0±3.3 0.33
Portal of entry
Pneumonia 38 (29) 14 (20) 24 (39) 0.02
Primary bacteremia 21 (16) 12 (17) 9 (15) 0.65
Cholangitis/cholecystitis 20 (15) 11 (16) 9 (15) 0.82
Skin and soft tissue infection (include post operation site infection) 14 (11) 7 (10.1) 7 (11.3) 0.83
UTI 13 (10) 11 (16) 2 (3) 0.02
Unknown 10 (8) 5 (7) 5 (8) 0.86
Intraabdomen infection 8 (6) 5 (7) 3 (5) 0.72
catheter-related BSI 7 (5) 4 (6) 3 (5) 1.00
Operation
General 41 (31) 17 (25) 24 (39) 0.12
Minor 29 (22) 13 (19) 16 (26) 0.45
Simple 84 (64) 41 (59) 43 (69) 0.32
Tracheostomy 25 (19) 11 (16) 14 (23) 0.46
Intensive care unit admission 74 (57) 29 (42) 45 (73) 0.001
Invasive catheter 124 (95) 63 (91) 61 (98) 0.16
Mechanical ventilation 60 (46) 22 (32) 38 (61) 0.001
APACHE II score 17.2±8.0 12.8±5.4 22.2±7.6 <0.001
Treatment
Adequate antibiotic therapy 106 (82) 62 (90) 46 (74) 0.03
Amikacin-based therapy 33 (31) 17 (27) 16 (38) 0.53
Colistin-based therapy 58 (54) 28 (45) 30 (65) 0.05
  1. Note: Data presented are numbers (%) of patients, unless otherwise indicated
  2. Abbreviation: SD Standard deviation, DM Diabetes mellitus, COPD Chronic obstructive pulmonary disease, UTI Urinary tract infection, APACHE Acute Physiology and Chronic Health Evaluation, CPE Carbapenemase-producing Enterobacteriaceae, TMP/SMX Trimethoprim/sulfamethoxazole