Table 2 Clinical characteristics of carbapenemase-producing Enterobacteriaceae bloodstream infection and antibiotics applied for its treatment
Characteristics | Total (N=131) | Survivor (N=69) | Non-survivor (N=62) | P |
|---|---|---|---|---|
Age ± SD (years) | 59.6±18.9 | 57.8±18.5 | 61.6±19.2 | 0.23 |
Male | 86 (66) | 46 (67) | 40 (65) | 0.25 |
Transfer history | 47 (36) | 24 (35) | 23 (37) | 0.93 |
Acquisition of infection | Â | Â | Â | 0.08 |
Community | 5 (4) | 5 (7) | 0 | 0.06 |
Healthcare-associated | 15 (12) | 8 (12) | 7 (11) | 0.96 |
Hospital-acquired | 111 (85) | 56 (81) | 55 (89) | 0.23 |
Comorbidity | ||||
Total | 112 (86) | 62 (90) | 50 (81) | 0.21 |
DM | 37 (28) | 16 (23) | 21 (34) | 0.25 |
Solid organ cancer | 34 (26) | 18 (26) | 16 (26) | 1.00 |
Hematology cancer | 33 (25) | 20 (29) | 13 (21) | 0.39 |
ESRD | 21 (16) | 11 (16) | 10 (16) | 1.00 |
Heart disease | 15 (12) | 7 (10) | 8 (13) | 0.83 |
Liver disease | 13 (9) | 7 (10) | 6 (10) | 1.00 |
Stroke | 12 (9) | 7 (10) | 5 (8) | 0.91 |
Immunosuppressive therapy state | 6 (5) | 2 (3) | 4 (7) | 0.58 |
COPD | 2 (2) | 0 | 2 (3) | 0.43 |
Charlson comorbidity index | 4.7±3.0 | 4.4±2.8 | 5.0±3.3 | 0.33 |
Portal of entry | ||||
Pneumonia | 38 (29) | 14 (20) | 24 (39) | 0.02 |
Primary bacteremia | 21 (16) | 12 (17) | 9 (15) | 0.65 |
Cholangitis/cholecystitis | 20 (15) | 11 (16) | 9 (15) | 0.82 |
Skin and soft tissue infection (include post operation site infection) | 14 (11) | 7 (10.1) | 7 (11.3) | 0.83 |
UTI | 13 (10) | 11 (16) | 2 (3) | 0.02 |
Unknown | 10 (8) | 5 (7) | 5 (8) | 0.86 |
Intraabdomen infection | 8 (6) | 5 (7) | 3 (5) | 0.72 |
catheter-related BSI | 7 (5) | 4 (6) | 3 (5) | 1.00 |
Operation | ||||
General | 41 (31) | 17 (25) | 24 (39) | 0.12 |
Minor | 29 (22) | 13 (19) | 16 (26) | 0.45 |
Simple | 84 (64) | 41 (59) | 43 (69) | 0.32 |
Tracheostomy | 25 (19) | 11 (16) | 14 (23) | 0.46 |
Intensive care unit admission | 74 (57) | 29 (42) | 45 (73) | 0.001 |
Invasive catheter | 124 (95) | 63 (91) | 61 (98) | 0.16 |
Mechanical ventilation | 60 (46) | 22 (32) | 38 (61) | 0.001 |
APACHE II score | 17.2±8.0 | 12.8±5.4 | 22.2±7.6 | <0.001 |
Treatment | ||||
Adequate antibiotic therapy | 106 (82) | 62 (90) | 46 (74) | 0.03 |
Amikacin-based therapy | 33 (31) | 17 (27) | 16 (38) | 0.53 |
Colistin-based therapy | 58 (54) | 28 (45) | 30 (65) | 0.05 |