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Table 3 Adjusted analysis of the association between guideline adherence, in-hospital and 30-day mortality

From: The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital inpatients: results from a Norwegian multicentre, observational cohort study

 

All patients

In-hospital mortality

30-day mortality

(N = 1756)

(n1 = 70)

(N = 1756)

P

(n2 = 142)

(N = 1756)

P

n (%)

n (%)

OR (95% CI)

n (%)

OR (95% CI)

Adherence to guideline

 No

667 (38.0)

38 (5.7)

1.00

 

75 (11.2)

1.00

 

 Yes

1089 (62.0)

32 (2.9)

0.46 (0.29, 0.74)

0.001

67 (6.2)

0.48 (0.29, 0.78)

0.003

Indication for antibiotic treatment

 LRTI

533 (30.4)

35 (6.6)

1.00

 

69 (13.0)

1.00

 

 COPD with LRTI

354 (20.2)

11 (3.1)

0.44 (0.22, 0.86)

0.017

22 (6.2)

0.45 (0.35, 0.59)

< 0.001

 Sepsis

291 (16.6)

14 (4.8)

0.69 (0.41, 1.15)

0.153

24 (8.3)

0.59 (0.36, 0.97)

0.038

 SSTI

187 (10.7)

1 (0.5)

0.12 (0.02, 0.66)

0.015

3 (1.6)

0.17 (0.03, 1.09)

0.061

 GI-infection

78 (4.4)

3 (3.9)

0.75 (0.10, 5.72)

0.782

6 (7.7)

0.78 (0.22, 2.80)

0.708

 UTI

179 (10.2)

2 (1.1)

0.12 (0.27, 0.55)

0.006

11 (6.2)

0.35 (0.19, 0.63)

0.001

 Other infections

134 (7.6)

4 (3.0)

0.35 (0.17, 0.72)

0.004

7 (5.2)

0.29 (0.19, 0.46)

< 0.001

Charlson Comorbidity Index

 CCI = 0

672 (38.3)

9 (1.3)

1.00

 

20 (3.0)

1.00

 

 CCI = 1

585 (33.3)

19 (3.3)

1.60 (0.52, 4.86)

0.411

36 (6.2)

1.40 (0.95, 2.04)

0.088

 CCI = 2

260 (14.8)

16 (6.2)

2.66 (0.72, 9.83)

0.143

31 (11.9)

2.67 (1.45, 4.90)

0.002

 CCI = 3

110 (6.3)

6 (5.5)

2.27 (0.60, 8.60)

0.228

16 (14.6)

3.18 (1.75, 5.78)

< 0.001

 CCI = 4

57 (3.3)

8 (14.0)

6.39 (1.64, 24.93)

0.008

14 (24.6)

6.79 (3.31, 13.95)

< 0.001

 CCI > 4

72 (4.1)

12 (16.7)

8.50 (3.80, 19.04)

< 0.001

25 (34.7)

12.04 (8.02, 18.08)

< 0.001

Age

  < =45

253 (14.4)

1 (0.4)

1.00

 

2 (0.8)

1.00

 

 46–65

396 (22.6)

7 (1.8)

2.35 (0.35, 15.70)

0.376

14 (3.5)

2.40 (0.53, 10.87)

0.257

 66–85

828 (47.2)

39 (4.7)

5.42 (0.82, 35.67)

0.079

80 (9.7)

5.61 (1.51, 20.85)

0.010

  > 85

279 (15.9)

23 (8.2)

10.13 (0.99, 103.78)

0.051

46 (16.5)

9.81 (1.91, 50.36)

0.006

Admitted from institution

 No

1501 (85.5)

46 (3.1)

1.00

 

88 (5.9)

1.00

 

 Yes

255 (14.5)

24 (9.4)

2.53 (1.45, 4.43)

0.001

54 (21.2)

3.74 (2.69, 5.20)

< 0.001

Sex

 Male

917 (52.2)

49 (5.3)

1.00

 

88 (9.6)

1.00

 

 Female

839 (47.8)

21 (2.5)

0.42 (0.28, 0.61)

< 0.001

54 (6.4)

0.59 (0.39, 0.90)

0.015

Week of admissiona

  

0.96 (0.93, 0.99)

0.005

 

0.96 (0.93, 0.997)

0.031

  1. aAdjustment for seasonality was performed by using the week of admission as adjustment variable
  2. In-hospital – and 30-day mortality was analysed using multivariate, logistic regression analysis with adjustment for clustering at individual sites. All variables are included in adjusted analysis. P-values in boldface are statistically significant (<0.05)
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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