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Table 3 Adjusted analysis of the association between guideline adherence, in-hospital and 30-day mortality

From: The association between adherence to national antibiotic guidelines and mortality, readmission and length of stay in hospital inpatients: results from a Norwegian multicentre, observational cohort study

  All patients In-hospital mortality 30-day mortality
(N = 1756) (n1 = 70) (N = 1756) P (n2 = 142) (N = 1756) P
n (%) n (%) OR (95% CI) n (%) OR (95% CI)
Adherence to guideline
 No 667 (38.0) 38 (5.7) 1.00   75 (11.2) 1.00  
 Yes 1089 (62.0) 32 (2.9) 0.46 (0.29, 0.74) 0.001 67 (6.2) 0.48 (0.29, 0.78) 0.003
Indication for antibiotic treatment
 LRTI 533 (30.4) 35 (6.6) 1.00   69 (13.0) 1.00  
 COPD with LRTI 354 (20.2) 11 (3.1) 0.44 (0.22, 0.86) 0.017 22 (6.2) 0.45 (0.35, 0.59) < 0.001
 Sepsis 291 (16.6) 14 (4.8) 0.69 (0.41, 1.15) 0.153 24 (8.3) 0.59 (0.36, 0.97) 0.038
 SSTI 187 (10.7) 1 (0.5) 0.12 (0.02, 0.66) 0.015 3 (1.6) 0.17 (0.03, 1.09) 0.061
 GI-infection 78 (4.4) 3 (3.9) 0.75 (0.10, 5.72) 0.782 6 (7.7) 0.78 (0.22, 2.80) 0.708
 UTI 179 (10.2) 2 (1.1) 0.12 (0.27, 0.55) 0.006 11 (6.2) 0.35 (0.19, 0.63) 0.001
 Other infections 134 (7.6) 4 (3.0) 0.35 (0.17, 0.72) 0.004 7 (5.2) 0.29 (0.19, 0.46) < 0.001
Charlson Comorbidity Index
 CCI = 0 672 (38.3) 9 (1.3) 1.00   20 (3.0) 1.00  
 CCI = 1 585 (33.3) 19 (3.3) 1.60 (0.52, 4.86) 0.411 36 (6.2) 1.40 (0.95, 2.04) 0.088
 CCI = 2 260 (14.8) 16 (6.2) 2.66 (0.72, 9.83) 0.143 31 (11.9) 2.67 (1.45, 4.90) 0.002
 CCI = 3 110 (6.3) 6 (5.5) 2.27 (0.60, 8.60) 0.228 16 (14.6) 3.18 (1.75, 5.78) < 0.001
 CCI = 4 57 (3.3) 8 (14.0) 6.39 (1.64, 24.93) 0.008 14 (24.6) 6.79 (3.31, 13.95) < 0.001
 CCI > 4 72 (4.1) 12 (16.7) 8.50 (3.80, 19.04) < 0.001 25 (34.7) 12.04 (8.02, 18.08) < 0.001
Age
  < =45 253 (14.4) 1 (0.4) 1.00   2 (0.8) 1.00  
 46–65 396 (22.6) 7 (1.8) 2.35 (0.35, 15.70) 0.376 14 (3.5) 2.40 (0.53, 10.87) 0.257
 66–85 828 (47.2) 39 (4.7) 5.42 (0.82, 35.67) 0.079 80 (9.7) 5.61 (1.51, 20.85) 0.010
  > 85 279 (15.9) 23 (8.2) 10.13 (0.99, 103.78) 0.051 46 (16.5) 9.81 (1.91, 50.36) 0.006
Admitted from institution
 No 1501 (85.5) 46 (3.1) 1.00   88 (5.9) 1.00  
 Yes 255 (14.5) 24 (9.4) 2.53 (1.45, 4.43) 0.001 54 (21.2) 3.74 (2.69, 5.20) < 0.001
Sex
 Male 917 (52.2) 49 (5.3) 1.00   88 (9.6) 1.00  
 Female 839 (47.8) 21 (2.5) 0.42 (0.28, 0.61) < 0.001 54 (6.4) 0.59 (0.39, 0.90) 0.015
Week of admissiona    0.96 (0.93, 0.99) 0.005   0.96 (0.93, 0.997) 0.031
  1. aAdjustment for seasonality was performed by using the week of admission as adjustment variable
  2. In-hospital – and 30-day mortality was analysed using multivariate, logistic regression analysis with adjustment for clustering at individual sites. All variables are included in adjusted analysis. P-values in boldface are statistically significant (<0.05)