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Table 2 MIC and FIX values of colistin in combination with antifungals from the checkerboard assay

From: In vitro polymyxin activity against clinical multidrug-resistant fungi

Strains tested Agents in combination MIC alone (μg/ml) MIC in the combination (μg/ml) FIC FIX Outcome
Rhodotorula mucilaginosa Colistin 16 1 0.06 0.5 Synergy
Fluconazole 128 64 0.5   
Candida albicans H5 Colistin 128 1 0.007 1 Additivity
Fluconazole 16 16 1   
Candida albicans H6 Colistin 128 64 0.5 0.5 Synergy
Itraconazole 32 2 0.06   
Colistin 128 1 0.007 0.5 Synergy
Amphotericin B 1 0.5 0.5   
Lichtheimia corymbifera ST87 Colistin 32 0.5 0.01 0.2 Synergy
Itraconazole 2 0.5 0.25   
Colistin 32 0.5 0.01 0.2 Synergy
Amphotericin B 2 0.5 0.25   
  1. FIC; Fractional Inhibitory concentration = MIC of the agent in the combination/MIC of the agent alone. FIX; Fractional Inhibitory Index is the sum of the FICs of the agents in the combination