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Fig. 3 | Antimicrobial Resistance & Infection Control

Fig. 3

From: Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria

Fig. 3

Comparison of the most significant antibiotic resistance gene types. a Relative abundance of the most significantly different antibiotic resistance genes (ARGs) identified among EVC001-fed infants and controls (P < 0.02; Bonferroni). Percentages are relative to the overall metagenome. These ARGs confer resistance to different drug classes, including beta-lactams, fluoroquinolones, and macrolides. The ARGs are grouped by gene name, followed by CARD identification entry (ARO). The colored bars represent respective drug class to which the ARG is known to confer resistance to. b Heatmap showing a hierarchical cluster analysis of the total ARGs identified (n = 652). Two groups were identified, one characterized by a lower-ARG carriage, containing most of the samples from infants fed EVC001 and one characterized by a higher overall carriage, containing most samples from infants in the control group. Genes clustered based on similar biological mechanisms implicated in drug resistance (see Results). P-values on the bar were computed using a Kruskal-Wallis test normalized with a Bonferroni correction

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