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Table 2 Clinical data of eight Agrobacterium cases

From: Agrobacterium spp. nosocomial outbreak assessment using rapid MALDI-TOF MS based typing, confirmed by whole genome sequencing

Isolate Main diagnosis at admission Rhizobium- related Diagnosisa Clinical Features at time of BC sampling N° positive BC/ BC drawn before treatment Polymicrobial BSI IVDs IVD culture Antibiotic treatment (days) Treatment duration (days) Outcome
A Elective surgery CLABSI Fever, chills 2/2 no CVC No growth Amoxicillin-clavulanic acid (2), Cefepime (3), ceftriaxone (5) 10, CVC removed on day 8 cured
B Semi-elective surgery BSI Fever 2/2 no PVC Not performed Amoxicillin-clavulanic acid (2), Meropenem + Ciprofloxacin (12) 14, removal date of PVC unknown cured
C Lung injury from smoke inhalation Transient bacteraemia Fever 1/2 no PVC Not performed Amoxicillin-clavulanic acid (3), Ceftriaxone (1) 4 cured
D Community-acquired pneumonia Transient bacteraemia asymptomatic 1/2 no PVC Not performed Amoxicillin-clavulanic acid (7, Doxycyclin (7) 7 cured
E Acute-myocardial infarction CRBSI Fever, chills 2/2 no PVC Agrobacterium sp. Piperacillin-tazobactam (2), Ceftraixone (7) 9, PVC removal day 4 cured
F Polyserositis related to Undifferentiated Connective Tissue Disease Transient bacteraemia asymptomatic 1/2 no PVC Not performed Cefepime (3) 3 cured
G Atypical mycobacterial pulmonary infection CLABSI Fever 1/2 Yes; Ochrobactrum anthrophi, Alcaligenes sp. Port Not performed Imipenem+cilastin 14, Port removal on day 9 cured
H Self-induced bleeding CLABSI Fever 2/3 Yes, Sphingomonas paucimobilis, Viridans group Streptococci CVC Sphingomonas paucimobilis, Viridans group Streptococci Amoxicillin-clavulanic acid 12, CVC removed on day 6 cured
  1. Abbreviations: BSI Bloodstream infection, CLABSI Central line associated bloodstream infection, CRBSI Catheter-related bloodstream infection, CVC Central venous catheter, D Days, IVD Intravascular device, PVC Peripheral venous catheter
  2. aEach Agrobacterium-related case was classified as follows: For central line associated BSI the Centers for Disease Control and Prevention (CDC) / National Healthcare Safety Network (NHSN) definition [34] was used. A catheter-related BSI was defined according to the respective Infectious Disease Society of America guideline [35]. A transient bacteremia was defined as a positive blood culture in an asymptomatic patient