Table 1 Baseline characteristics
OAP (N = 39) | Placebo (N = 39) | |
|---|---|---|
Age in years | 67 (61–72) | 69 (61–73) |
Male sex | 28/39 (71.8) | 25/39 (64.1) |
ASA classification ≤2 | 26/38 (68.4) | 30/36 (83.3) |
Charlson Comorbidity Index | ||
1–2 | 22/39 (56.4) | 25/39 (64.1) |
3–4 | 9/39 (23.1) | 2/39 (5.2) |
≥ 5 | 8/39 (20.5) | 12/39 (30.1) |
Immunosuppressive therapy a | 0/39 (0.0) | 2/39 (5.2) |
BMI in kg/m3, median (IQR) | 28 (24–31) | 26 (23–29) |
Obese (BMI > 30) | 9/39 (23.1) | 5/38 (13.2) |
Abdominal surgery in the previous year | 1/39 (2.3) | 2/39 (5.2) |
Oral mechanical bowel preparation | 1/39 (2.3) | 2/39 (5.2) |
Indication for surgery | ||
Colorectal malignancy | 38/39 (97.4) | 39/39 (100) |
Inflammatory bowel disease | 1/39 (2.3) | 0/39 (0.0) |
Wound class | ||
Clean-contaminated (class 2) | 37/39 (94.9) | 39/39 (100) |
Contaminated (class 3) | 2/39 (5.1) | 0/39 (0.0) |
Type of resection | ||
Right sided hemicolectomy | 13/39 (33.3) | 9/39 (23.1) |
Left sided hemicolectomy | 2/39 (5.2) | 4/39 (10.3) |
Sigmoid resection | 10/39 (25.6) | 8/39 (20.5) |
Low anterior resection or rectum amputation | 10/39 (25.6) | 15/39 (38.5) |
(Sub) total colectomy | 2/39 (5.2) | 0/39 (0.0) |
Other | 2/39 (5.2) | 3/39 (7.7) |
Surgical approach | ||
Laparotomy | 4/39 (10.3) | 4/39 (10.3) |
Laparoscopy b | 28/39 (72.0) | 26/39 (66.7) |
Robotic laparoscopy | 7/39 (17.8) | 9/39 (23.1) |
Duration of surgery in minutes, median (IQR) | 148 (117–185) | 150 (116–215) |
Duration >75th percentile c | 8/38 (21.1) | 13/37 (35.1) |
Normothermia after procedure | 22/28 (78.6) | 25/31 (80.1) |
Stoma | 6/38 (15.8) | 14/39 (35.9) |
Perioperative intravenous antibiotic prophylaxis | 37/39 (94.9) | 37/38 (97.3) |
Complete compliance to study medication (all 12 doses) | 23/33 (69.7) | 22/33 (66.7) |