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Table 1 Baseline characteristics

From: Prevention of severe infectious complications after colorectal surgery using oral non-absorbable antimicrobial prophylaxis: results of a multicenter randomized placebo-controlled clinical trial

 OAP
(N = 39)
Placebo
(N = 39)
Age in years67 (61–72)69 (61–73)
Male sex28/39 (71.8)25/39 (64.1)
ASA classification ≤226/38 (68.4)30/36 (83.3)
Charlson Comorbidity Index
 1–222/39 (56.4)25/39 (64.1)
 3–49/39 (23.1)2/39 (5.2)
  ≥ 58/39 (20.5)12/39 (30.1)
Immunosuppressive therapy a0/39 (0.0)2/39 (5.2)
BMI in kg/m3, median (IQR)28 (24–31)26 (23–29)
 Obese (BMI > 30)9/39 (23.1)5/38 (13.2)
Abdominal surgery in the previous year1/39 (2.3)2/39 (5.2)
Oral mechanical bowel preparation1/39 (2.3)2/39 (5.2)
Indication for surgery
 Colorectal malignancy38/39 (97.4)39/39 (100)
 Inflammatory bowel disease1/39 (2.3)0/39 (0.0)
Wound class
 Clean-contaminated (class 2)37/39 (94.9)39/39 (100)
 Contaminated (class 3)2/39 (5.1)0/39 (0.0)
Type of resection
 Right sided hemicolectomy13/39 (33.3)9/39 (23.1)
 Left sided hemicolectomy2/39 (5.2)4/39 (10.3)
 Sigmoid resection10/39 (25.6)8/39 (20.5)
 Low anterior resection or rectum amputation10/39 (25.6)15/39 (38.5)
 (Sub) total colectomy2/39 (5.2)0/39 (0.0)
 Other2/39 (5.2)3/39 (7.7)
Surgical approach
 Laparotomy4/39 (10.3)4/39 (10.3)
 Laparoscopy b28/39 (72.0)26/39 (66.7)
 Robotic laparoscopy7/39 (17.8)9/39 (23.1)
Duration of surgery in minutes, median (IQR)148 (117–185)150 (116–215)
 Duration >75th percentile c8/38 (21.1)13/37 (35.1)
Normothermia after procedure22/28 (78.6)25/31 (80.1)
Stoma6/38 (15.8)14/39 (35.9)
Perioperative intravenous antibiotic prophylaxis37/39 (94.9)37/38 (97.3)
Complete compliance to study medication (all 12 doses)23/33 (69.7)22/33 (66.7)
  1. Data are presented as n/N with data (%), unless specified otherwise. ASA, American Society of Anesthesiologists; BMI, body mass index; IQR, interquartile range; OAP, oral antibiotic prophylaxis
  2. a Because of chemotherapy
  3. b Of which 6 (15.4%) were converted to open procedures in OAP arm and 1 (2.3%) in placebo arm
  4. c 75th percentiles of duration of surgery, based on type of resection and approach [22]