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Table 4 Expression of efflux pump genes in evolved, resistant P. aeruginosa, selected by levofloxacina

From: Development of in vitro resistance to fluoroquinolones in Pseudomonas aeruginosa

Passage

mexA

mexC

mexE

mexX

0. (0MIC)

1.0000

1.0000

1.0000

1.0000

1. (1/2MIC)

0.6700

2.6295

1.4200

1.3850

2. (1MIC)

1.2310

8.6650

5.4625

2.2925

3. (2MIC)

0.9325

16.2745

8.3645

1.2030

4. (4MIC)

0.8605

152.1040

2.6225

3.0995

5. (8MIC)

1.2310

52.7525

12.0805

1.3095

6. (16MIC)

1.0385

57.6390

15.4695

2.0900

7. (32MIC)

1.4255

145.8855

10.5065

4.6735

8. (64MIC)

1.5140

74.2490

12.8310

7.5555

  1. aRelative expression levels represent the median of the six lineages