Antibiotic appropriateness and adherence to local guidelines in perioperative prophylaxis: results from an antimicrobial stewardship intervention

Table 2 SAP appropriateness

Variable	Total sample	2013	2019	p value
Overall appropriateness^a, n (%)	370 (46,9)	149 (36,6)	221 (57,9)	< 0,0001
Appropriateness in indication^b	594 (75,3)	238 (58,5)	356 (93,2)	< 0,0001
Appropriateness in selection and dosing^c	546 (69,2)	238 (58,5)	308 (80,6)	< 0,0001
Appropriateness in timing^d	749 (94,9)	376 (92,4)	373 (97,6)	= 0,001
Appropriateness in duration^e	595 (75,4)	289 (71)	306 (80,1)	= 0,002
Multi-dimensional inappropriateness^f
within total cases, %	28,1 (221/789)	44,7 (182/407)	10,2 (39/382)	< 0,0001
within inappropriate cases, %	52,7 (221/419)	70,5 (182/258)	24,2 (39/161)

^a SAP prescriptions fully adherent to local guidelines
^b SAP administered only if indicated in local guidelines or not administered if not recommended for the specific surgical
procedure
^c Correct choice and dosing of the antimicrobial agent, including repeated doses in cases of procedures lasting > 4 h
^d SAP administered within 120 min from the incision
^e SAP discontinued within 24 h from surgery, or within 48 h from open-heart surgery
^f SAP prescriptions non adherent to local guidelines for ≥2 dimensions

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