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Table 2 SAP appropriateness

From: Antibiotic appropriateness and adherence to local guidelines in perioperative prophylaxis: results from an antimicrobial stewardship intervention

Variable Total sample 2013 2019 p value
Overall appropriatenessa, n (%) 370 (46,9) 149 (36,6) 221 (57,9) <  0,0001
Appropriateness in indicationb 594 (75,3) 238 (58,5) 356 (93,2) <  0,0001
Appropriateness in selection and dosingc 546 (69,2) 238 (58,5) 308 (80,6) < 0,0001
Appropriateness in timingd 749 (94,9) 376 (92,4) 373 (97,6) = 0,001
Appropriateness in duratione 595 (75,4) 289 (71) 306 (80,1) = 0,002
Multi-dimensional inappropriatenessf
 within total cases, % 28,1 (221/789) 44,7 (182/407) 10,2 (39/382) < 0,0001
 within inappropriate cases, % 52,7 (221/419) 70,5 (182/258) 24,2 (39/161)  
  1. a SAP prescriptions fully adherent to local guidelines
  2. b SAP administered only if indicated in local guidelines or not administered if not recommended for the specific surgical
  3. procedure
  4. c Correct choice and dosing of the antimicrobial agent, including repeated doses in cases of procedures lasting > 4 h
  5. d SAP administered within 120 min from the incision
  6. e SAP discontinued within 24 h from surgery, or within 48 h from open-heart surgery
  7. f SAP prescriptions non adherent to local guidelines for ≥2 dimensions