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Table 2 Univariate and multivariate analyses of risk factors for patients with CPE colonization

From: Epidemiology and risk factors of rectal colonization of carbapenemase-producing Enterobacteriaceae among high-risk patients from ICU and HSCT wards in a university hospital

Variable CRE Colonization (n = 25) Control (n = 75) Univariate analysis Multivariate analysis
OR (95% CI) P-value OR (95% CI) P-value
Patient characteristics
 Man gender (Male) 14 (56.00%) 48 (64.00%) 0.65 (0.21–2.00) 0.45   
 Age 63.48 ± 22.81 60.76 ± 19.01 1.01 (0.98–1.05) 0.36   
 Transferring from another hospital 10 (40.00%) 37 (49.33%) 0.92 (0.29–2.92) 0.88   
Underlying diseases
 PITT Scores 2.28 ± 1.86 2.98 ± 2.09 0.79 (0.54–1.15) 0.22   
 APACHE II Scores 17.16 ± 7.18 15.74 ± 8.13 1.10 (1.01–1.20) 0.05 0.40 (0.09–1.71) 0.22
 Hypertension 13 (52.00%) 38 (50.66%) 0.62 (0.18–2.15) 0.42   
 Diabetes 12 (48.00%) 20 (26.67%) 3.97 (1.16–13.62) 0.03 4.30 (0.67–27.306) 0.12
 Tuberculosis 2 (8.00%) 4 (5.33%) 0.94 (0.10–8.50) 0.95   
 Hepatitis B 2 (8.00%) 3 (4.00%) 2.17 (0.24–19.57) 0.09   
 Tumour 12 (48.00%) 21 (28.00%) 2.88 (0.85–9.72) 0.09   
 Respiratory diseases 17 (68.00%) 36 (48.00%) 2.64 (0.76–9.14) 0.13   
 COPD 9 (36.00%) 5 (6.67%) 0.92 (0.20–4.20) 0.91   
 Hepatobiliary disease 8 (32.00%) 26 (34.67%) 0.63 (0.18–2.10) 0.47   
 Gastrointestinal disease 6 (24.00%) 27 (36.00%) 0.36 (0.09–1.46) 0.15   
 Chronic kidney disease 6 (24.00%) 21 (28.00%) 0.75 (0.21–2.70) 0.66   
 Urinary system disease 10 (40.00%) 6 (8.00%) 7.71 (2.21–26.83) 0.001 18.06 (3.31–98.62) 0.001
 Cardiovascular disease 15 (60.00%) 41 (54.67%) 0.87 (0.27–2.80) 0.82   
 Coronary heart disease 7 (28.00%) 10 (13.33%) 4.26 (1.12–16.28) 0.03 3.29 (0.91–11.98) 0.07
 Neurological disease 9 (36.00%) 18 (24.00%) 2.27 (0.64–7.99) 0.20   
 Disease of immune system 1 (4.00%) 5 (6.67%) 0.22 (0.02–2.85) 0.25   
 Hematological system diseases 4 (16.00%) 16 (21.33%) 1.47 (0.32–6.72) 0.62   
 Endocrine System Diseases 15 (60.00%) 28 (37.33%) 3.16 (1.05–9.54) 0.04 1.62 (0.33–7.99) 0.55
 Surgery in the past 6 months 2 (8.00%) 16 (21.33%) 0.32 (0.05–1.99) 0.22   
 Multiple organ dysfunction syndrome 6 (24.00%) 8 (10.67%) 6.27 (1.35–29.05) 0.02   
 Transplant 4 (16.00%) 11 (14.67%) 1.82 (0.43–7.64) 0.42   
 Urinary tract infection 10 (40.00%) 12 (16.00%) 3.64 (0.78–16.87) 0.09   
 Respiratory infection 21 (84.00%) 51 (68.00%) 2.20 (0.37–12.92) 0.38   
 Abdominal infection 8 (32.00%) 2 (2.67%) 0.48 (0.05–4.68) 0.53   
 Septic shock 1 (4.00%) 9 (12.00%) 0.99 (0.95–1.02) 0.53   
 Severe anemia 5 (20.00%) 17 (26.15%) 1.06 (0.27–4.13) 0.94   
 Glucocorticoid 7 (28.00%) 12 (16.00%) 2.58 (0.86–9.72) 0.21   
 Cardiotonic 2 (8.00%) 5 (6.67%) 0.78 (0.08–7.87) 0.84   
 Receipt of total parenteral Nutrition (days) 39.00 ± 57.47 16.71 ± 25.33 0.99 (0.95–1.02) 0.53   
 Urinary catheter (days) 56.08 ± 60.35 21.80 ± 26.07 1.04 (0.99–1.09) 0.08   
 Nasal catheter (days) 35.38 ± 48.75 21.59 ± 36.98 0.97 (0.92–1.04) 0.16   
 Mechanical ventilation (days) 34.64 ± 48.61 15.15 ± 19.01 1.02 (0.98–1.09) 0.16   
 Trachea cannula 24.80 ± 48.02 12.65 ± 24.27 0.98 (0.95–1.03) 0.55   
 Tracheotomy 10 (40.00%) 31 (41.33%) 0.17 (0.02–1.28) 0.08   
 Bronchoscopy 12 (48.00%) 13 (17.33%) 8.15 (1.61–41.22) 0.01 4.05 (1.30–12.60) 0.01
 Drainage tube 19 (76.00%) 55 (73.33%) 0.31 (0.05–1.76) 0.18   
 Penicillin 5 (20.00%) 17 (22.67%) 0.60 (0.14–2.55) 0.48   
 Cephalosporins 8 (32.00%) 25 (33.33%) 0.37 (0.08–1.61) 0.19   
 Carbapenem 10 (40.00%) 24 (32.00%) 1.12 (0.32–3.84) 0.86   
 Fluoroquinolone 5 (20.00%) 11 (14.67%) 0.87 (018–4.30) 0.87   
 Tetracycline 3 (12.00%) 4 (5.33%) 0.93 (0.14–5.90) 0.92   
 Glycopeptide 3 (12.00%) 12 (16.00%) 0.20 (0.03–1.15) 0.07   
 Tigecycline 4 (16.00%) 3 (4.00%) 1.94 (0.27–13.98) 0.51   
 Combined use of antibiotics 18 (72.00%) 32 (42.67%) 5.91 (1.20–29.16) 0.03 3.60 (1.18–10.93) 0.02
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