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Table 2 Univariate and multivariate analyses of risk factors for patients with CPE colonization

From: Epidemiology and risk factors of rectal colonization of carbapenemase-producing Enterobacteriaceae among high-risk patients from ICU and HSCT wards in a university hospital

Variable

CRE Colonization (n = 25)

Control (n = 75)

Univariate analysis

Multivariate analysis

OR (95% CI)

P-value

OR (95% CI)

P-value

Patient characteristics

 Man gender (Male)

14 (56.00%)

48 (64.00%)

0.65 (0.21–2.00)

0.45

  

 Age

63.48 ± 22.81

60.76 ± 19.01

1.01 (0.98–1.05)

0.36

  

 Transferring from another hospital

10 (40.00%)

37 (49.33%)

0.92 (0.29–2.92)

0.88

  

Underlying diseases

 PITT Scores

2.28 ± 1.86

2.98 ± 2.09

0.79 (0.54–1.15)

0.22

  

 APACHE II Scores

17.16 ± 7.18

15.74 ± 8.13

1.10 (1.01–1.20)

0.05

0.40 (0.09–1.71)

0.22

 Hypertension

13 (52.00%)

38 (50.66%)

0.62 (0.18–2.15)

0.42

  

 Diabetes

12 (48.00%)

20 (26.67%)

3.97 (1.16–13.62)

0.03

4.30 (0.67–27.306)

0.12

 Tuberculosis

2 (8.00%)

4 (5.33%)

0.94 (0.10–8.50)

0.95

  

 Hepatitis B

2 (8.00%)

3 (4.00%)

2.17 (0.24–19.57)

0.09

  

 Tumour

12 (48.00%)

21 (28.00%)

2.88 (0.85–9.72)

0.09

  

 Respiratory diseases

17 (68.00%)

36 (48.00%)

2.64 (0.76–9.14)

0.13

  

 COPD

9 (36.00%)

5 (6.67%)

0.92 (0.20–4.20)

0.91

  

 Hepatobiliary disease

8 (32.00%)

26 (34.67%)

0.63 (0.18–2.10)

0.47

  

 Gastrointestinal disease

6 (24.00%)

27 (36.00%)

0.36 (0.09–1.46)

0.15

  

 Chronic kidney disease

6 (24.00%)

21 (28.00%)

0.75 (0.21–2.70)

0.66

  

 Urinary system disease

10 (40.00%)

6 (8.00%)

7.71 (2.21–26.83)

0.001

18.06 (3.31–98.62)

0.001

 Cardiovascular disease

15 (60.00%)

41 (54.67%)

0.87 (0.27–2.80)

0.82

  

 Coronary heart disease

7 (28.00%)

10 (13.33%)

4.26 (1.12–16.28)

0.03

3.29 (0.91–11.98)

0.07

 Neurological disease

9 (36.00%)

18 (24.00%)

2.27 (0.64–7.99)

0.20

  

 Disease of immune system

1 (4.00%)

5 (6.67%)

0.22 (0.02–2.85)

0.25

  

 Hematological system diseases

4 (16.00%)

16 (21.33%)

1.47 (0.32–6.72)

0.62

  

 Endocrine System Diseases

15 (60.00%)

28 (37.33%)

3.16 (1.05–9.54)

0.04

1.62 (0.33–7.99)

0.55

 Surgery in the past 6 months

2 (8.00%)

16 (21.33%)

0.32 (0.05–1.99)

0.22

  

 Multiple organ dysfunction syndrome

6 (24.00%)

8 (10.67%)

6.27 (1.35–29.05)

0.02

  

 Transplant

4 (16.00%)

11 (14.67%)

1.82 (0.43–7.64)

0.42

  

 Urinary tract infection

10 (40.00%)

12 (16.00%)

3.64 (0.78–16.87)

0.09

  

 Respiratory infection

21 (84.00%)

51 (68.00%)

2.20 (0.37–12.92)

0.38

  

 Abdominal infection

8 (32.00%)

2 (2.67%)

0.48 (0.05–4.68)

0.53

  

 Septic shock

1 (4.00%)

9 (12.00%)

0.99 (0.95–1.02)

0.53

  

 Severe anemia

5 (20.00%)

17 (26.15%)

1.06 (0.27–4.13)

0.94

  

 Glucocorticoid

7 (28.00%)

12 (16.00%)

2.58 (0.86–9.72)

0.21

  

 Cardiotonic

2 (8.00%)

5 (6.67%)

0.78 (0.08–7.87)

0.84

  

 Receipt of total parenteral Nutrition (days)

39.00 ± 57.47

16.71 ± 25.33

0.99 (0.95–1.02)

0.53

  

 Urinary catheter (days)

56.08 ± 60.35

21.80 ± 26.07

1.04 (0.99–1.09)

0.08

  

 Nasal catheter (days)

35.38 ± 48.75

21.59 ± 36.98

0.97 (0.92–1.04)

0.16

  

 Mechanical ventilation (days)

34.64 ± 48.61

15.15 ± 19.01

1.02 (0.98–1.09)

0.16

  

 Trachea cannula

24.80 ± 48.02

12.65 ± 24.27

0.98 (0.95–1.03)

0.55

  

 Tracheotomy

10 (40.00%)

31 (41.33%)

0.17 (0.02–1.28)

0.08

  

 Bronchoscopy

12 (48.00%)

13 (17.33%)

8.15 (1.61–41.22)

0.01

4.05 (1.30–12.60)

0.01

 Drainage tube

19 (76.00%)

55 (73.33%)

0.31 (0.05–1.76)

0.18

  

 Penicillin

5 (20.00%)

17 (22.67%)

0.60 (0.14–2.55)

0.48

  

 Cephalosporins

8 (32.00%)

25 (33.33%)

0.37 (0.08–1.61)

0.19

  

 Carbapenem

10 (40.00%)

24 (32.00%)

1.12 (0.32–3.84)

0.86

  

 Fluoroquinolone

5 (20.00%)

11 (14.67%)

0.87 (018–4.30)

0.87

  

 Tetracycline

3 (12.00%)

4 (5.33%)

0.93 (0.14–5.90)

0.92

  

 Glycopeptide

3 (12.00%)

12 (16.00%)

0.20 (0.03–1.15)

0.07

  

 Tigecycline

4 (16.00%)

3 (4.00%)

1.94 (0.27–13.98)

0.51

  

 Combined use of antibiotics

18 (72.00%)

32 (42.67%)

5.91 (1.20–29.16)

0.03

3.60 (1.18–10.93)

0.02