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Table 4 Antimicrobial regimens for the treatment of Acinetobacter baumannii bacteremic pneumonia (appropriate antibiotics)

From: Influence of severity of infection on the effect of appropriate antimicrobial therapy for Acinetobacter baumannii bacteremic pneumonia

Main agents useda,b No. (%) of patients
(n = 151)
APACHE II score, median (IQR)d No. (%) of patients
Combination therapye 14-Day
Mortality
P-value 28-Day
Mortality
P-value
Anti-pseudomonas penicillin-based therapy 13 (8.6) 245 (19–29) 8 (61.5) 6 (46.2) 0.513 8 (61.5) .319
Anti-pseudomonas cephalosporin-based therapy 31 (20.5) 25 (19–32) 24 (77.4) 10 (32.3) 0.479 12 (38.7) .229
Carbapenem-based therapy 59 (39.1) 25 (18–28) 25 (42.4) 20 (33.9) 0.434 28 (47.5) .861
Colistin-based therapy 55 (36.4) 25 (19–29) 49 (89.1) 28 (50.9) 0.012 33 (60.0) .030
Tigecycline-based therapy 54 (35.8) 28 (22–32) 46 (85.2) 28 (51.9) 0.008 32 (59.3) .045
Fluoroquinolone-based therapy 7 (4.6) 25 (12–36) 3 (42.9) 4 (57.1) 0.278 4 (57.1) .633
Sulbactam-based therapy 24 (15.9) 26 (22–28) 13 (54.2) 7 (29.2) 0.344 10 (41.7) .475
Carbapenem + colistin-based therapy 15 (9.9) 24 (18–28) 6 (40.0) 9 (60.0) 0.061 11 (73.3) .041
Carbapenem + tigecycline-based therapy 12 (8.0) 25 (22–28) 7 (58.3) 9 (75.0) 0.006 10 (83.3) .011
Carbapenem + sulbactam-based therapy 6 (4.0) 25 (22–28) 5 (83.3) 4 (66.7) 0.200 5 (83.3) .107
Colistin + tigecycline-based therapy 25 (16.6) 27 (20–32) 12 (48.0) 14 (56.0) 0.039 15 (60.0) .202
Carbapenem + colistin + tigecycline-based therapy 4 (2.7) 24 (20–28) 2 (50.0) 4 (100.0) 0.019 4 (100.0) .052
Antimicrobial regimensc
 Anti-pseudomonas penicillin only 5 (3.3) 24 (19–30)   2 (40.0) 1.000 4 (80.0) .198
 Anti-pseudomonas cephalosporin only 7 (4.6) 23 (16–30)   2 (28.6) 0.711 2 (28.6) .444
 Carbapenem + colistin 9 (6.0) 24 (18–26)   4 (44.4) 0.730 6 (66.7) .315
 Carbapenem + tigecycline 5 (3.3) 25 (26–28)   3 (60.0) 0.366 3 (60.0) .673
 Carbapenem + sulbactam 1 (0.7) 17   0 1.000 0 1.000
 Carbapenem + tigecycline + colistin 2 (1.3) 17, 22   2 (100) 0.141 2 (100) .232
 Tigecycline only 8 (5.3) 29 (28–33)   5 (62.5) 0.155 5 (62.5) .484
 Colistin + tigecycline 13 (8.6) 29 (22–38)   7 (53.9) 0.210 7 (53.9) .678
  1. aAn antimicrobial agent (or antimicrobial agents)-based therapy denotes the corresponding antimicrobial agent(s) alone or in combination with other antimicrobial agent(s)
  2. b“Colistin” denotes intravenous colistin only. Inhaled colistin is not included
  3. cNot in combination with other antimicrobial agents
  4. dIQR, interquartile range. When the case number is less than 4, the APACHE II score for each case is shown
  5. eCombination therapy is defined as administration of more than one antimicrobial agent