Main agents useda,b | No. (%) of patients (n = 185) | APACHE II score, median (IQR)d | No. (%) of patients | ||||
---|---|---|---|---|---|---|---|
Combination therapye | 14-Day Mortality | P-value | 28-Day Mortality | P-value | |||
Anti-pseudomonas penicillin-based therapy | 28 (15.1) | 33 (24–39) | 3 (10.7) | 19 (67.9) | .142 | 22 (78.6) f | .077 |
Anti-pseudomonas cephalosporin-based therapy | 36 (19.5) | 31 (21–40) | 8 (22.2) | 17 (47.2) | .287 | 22 (61.1) | .710 |
Carbapenem-based therapy | 61 (33.0) | 29 (24–38) | 11 (18.0) | 38 (62.3) | .170 | 45 (73.8) | .047 |
Colistin-based therapy | 7 (3.8) | 28 (21–30) | 7 (100) | 3 (42.9) | .702 | 6 (85.7) | .425 |
Tigecycline-based therapy | 13 (7.0) | 33 (25–39) | 10 (76.9) | 9 (69.2) | .390 | 10 (76.9) | .382 |
Fluoroquinolone-based therapy | 10 (5.4) | 28 (20–39) | 3 (30.0) | 5 (50.0) | .737 | 7 (70.0) | 1 |
Sulbactam-based therapy | 10 (5.4) | 30 (18–37) | 6 (60.0) | 5 (50.0) | .737 | 7 (70.0) | 1 |
Carbapenem + colistin-based therapy | 3 (1.6) | 19, 27, 28 | 1 (33.3) | 0 | .088 | 3 (100) | .555 |
Carbapenem + tigecycline-based therapy | 4 (2.2) | 27 (22–31) | 2 (50.0) | 2 (50.0) | 1 | 3 (75.0) | 1 |
Carbapenem + sulbactam-based therapy | 5 (2.7) | 31 (29–31) | 3 (60.0) | 3 (60.0) | 1 | 4 (80.0) | .655 |
Colistin + tigecycline-based therapy | 2 (1.1) | 19, 40 | 1 (50.0) | 1 (50.0) | 1 | 2 (100) | .535 |
Carbapenem + colistin + tigecycline-based therapy | 1 (0.5) | 19 | 0 | 0 | .449 | 1 (100) | 1 |
Antimicrobial regimensc | |||||||
Anti-pseudomonas penicillin only | 25 (13.5) | 33 (24–39) | 18 (72.0) | .068 | 20 (80.0) | .070 | |
Anti-pseudomonas cephalosporin only | 28 (15.1) | 32 (22–41) | 14 (50.0) | .553 | 17 (60.0) | .714 | |
Carbapenem + colistin | 2 (1.1) | 27, 28 | 0 | .200 | 2 (100.0) | .535 | |
Carbapenem + tigecycline | 2 (1.1) | 25, 33 | 1 (50.0) | 1 | 1 (50.0) | 1 | |
Carbapenem + sulbactam | 2 (1.1) | 31, 40 | 2 (100) | .503 | 2 (100) | .535 | |
Carbapenem + fluoroquinolone | 1 (0.5) | 43 | 1 (100) | 1 | 1(100) | 1 | |
Carbapenem + tigecycline + colistin | 1 (0.5) | 19 | 0 | .449 | 1(100) | 1 | |
Tigecycline only | 3 (1.6) | 30, 33, 38 | 3 (100) | .254 | 3 (100) | .555 | |
Colistin + tigecycline | 1 (0.5) | 40 | 1 (100) | 1 | 1 (100) | 1 |