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Table 3 Resistome of carbapenem-resistant Enterobacteriaceae based on genome analysis of three isolates from Alexander River estuary and Beit Yanai beach. Only results passing the strict threshold are shown

From: Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat

ARO term of top hit in CARD %ID nEC133 %ID nEC134 %ID nEC135 Resistance Gene Family
IMI-2 100 97 97 IMI beta-lactamase
NmcR 96 95 95 NmcA beta-lactamase
ACT-28 91 91 91 ACT beta-lactamase
E. coli AmpH beta-lactamase 85 85 85 ampC-type beta-lactamase
H. influenzae PBP3 52 53 53 Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics
FosA4 70 70 70 fosfomycin thiol transferase
BacA** 95 95 95 undecaprenyl pyrophosphate related proteins
E. coli EF-Tu mutants 98 98 98 elfamycin resistant EF-Tu
AdeF 61 61 61 RND antibiotic efflux pump
AdeF* 41 41 41 RND antibiotic efflux pump
AdeF* 41 41 41 RND antibiotic efflux pump
BaeR 95 95 95 RND antibiotic efflux pump
CRP 99 99 99 RND antibiotic efflux pump
E. cloacae AcrA 99 99 99 RND antibiotic efflux pump
E. coli MarR mutant 88 89 89 RND antibiotic efflux pump
OqxA 92 92 91 RND antibiotic efflux pump
MarA 94 94 94 RND antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams
RamA 95 96 96 RND antibiotic efflux pump;
General Bacterial Porin with reduced permeability to beta-lactams
H-NS 96 96 96 RND/MFS antibiotic efflux pump
EmrR 93 93 93 MFS antibiotic efflux pump
K. pneumoniae KpnE 82 82 82 MFS antibiotic efflux pump
K. pneumoniae KpnF 86 86 86 MFS antibiotic efflux pump
K. pneumoniae KpnH 92 93 93 MFS antibiotic efflux pump
MsbA 95 95 95 ATP-binding cassette (ABC) antibiotic efflux pump
  1. CARD The Comprehensive Antibiotic Resistance Database, ARO Antibiotic Resistance Ontology, %ID Percent identity of match to top hit in CARD
  2. *Strict only in nEC133
  3. **Distinct sequences