Table 3 Resistome of carbapenem-resistant Enterobacteriaceae based on genome analysis of three isolates from Alexander River estuary and Beit Yanai beach. Only results passing the strict threshold are shown

IMI-2

100

97

97

IMI beta-lactamase

NmcR

96

95

95

NmcA beta-lactamase

ACT-28

91

91

91

ACT beta-lactamase

E. coli AmpH beta-lactamase

85

85

85

ampC-type beta-lactamase

H. influenzae PBP3

52

53

53

Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics

FosA4

70

70

70

fosfomycin thiol transferase

BacA**

95

95

95

undecaprenyl pyrophosphate related proteins

E. coli EF-Tu mutants

98

98

98

elfamycin resistant EF-Tu

AdeF

61

61

61

RND antibiotic efflux pump

AdeF*

41

41

41

RND antibiotic efflux pump

AdeF*

41

41

41

RND antibiotic efflux pump

BaeR

95

95

95

RND antibiotic efflux pump

CRP

99

99

99

RND antibiotic efflux pump

E. cloacae AcrA

99

99

99

RND antibiotic efflux pump

E. coli MarR mutant

88

89

89

RND antibiotic efflux pump

OqxA

92

92

91

RND antibiotic efflux pump

MarA

94

94

94

RND antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams

RamA

95

96

96

RND antibiotic efflux pump;

General Bacterial Porin with reduced permeability to beta-lactams

H-NS

96

96

96

RND/MFS antibiotic efflux pump

EmrR

93

93

93

MFS antibiotic efflux pump

K. pneumoniae KpnE

82

82

82

MFS antibiotic efflux pump

K. pneumoniae KpnF

86

86

86

MFS antibiotic efflux pump

K. pneumoniae KpnH

92

93

93

MFS antibiotic efflux pump

MsbA

95

95

95

ATP-binding cassette (ABC) antibiotic efflux pump