Skip to main content

Table 4 Meta-analysis of risk factors for CRKP infection in the type 2 comparison

From: Risk factors for carbapenem-resistant Klebsiella pneumoniae infection relative to two types of control patients: a systematic review and meta-analysis

 

Number of included studies

Sample size (CRKP infection/Without CRKP infection)

Heterogeneity

Effects model

OR [95% CI]

Z

P

Egger’s test

P >|t|

χ2

P

I2

Admission to ICU

4

576/1572

41.44

<0.00001

93%

Random

4.44 [1.32, 14.95]

2.40

0.02*

0.313

Diabetes

6

523/1718

6.59

0.25

24%

Fixed

1.36 [0.99, 1.86]

1.92

0.05

0.199

Hypertension

3

94/860

3.83

0.15

48%

Fixed

1.06 [0.65, 1.72]

0.23

0.82

0.127

HBV

3

39/497

1.41

0.49

0%

Fixed

0.79 [0.31, 2.02]

0.50

0.62

0.116

HCV

4

86/613

3.88

0.27

23%

Fixed

1.41 [0.85, 2.34]

1.33

0.19

0.083

HCC

4

86/613

7.78

0.05

61%

Random

1.14 [0.43, 3.02]

0.26

0.80

0.488

Alcoholic liver disease

3

78/311

0.23

0.89

0%

Fixed

1.13 [0.65, 1.97]

0.44

0.66

0.555

Retransplantation

3

54/571

7.39

0.02

73%

Random

3.70 [0.74, 18.58]

1.59

0.11

0.590

Tracheostomy

3

161/245

0.17

0.92

0%

Fixed

8.48 [4.43, 16.22]

6.46

<0.00001*

0.375

Mechanical ventilation

5

693/1539

67.27

<0.00001

94%

Random

4.78 [1.78, 12.82]

3.10

0.002*

0.652

CVC

4

632/1473

34.74

<0.00001

91%

Random

3.85 [1.56, 9.52]

2.92

0.004*

0.996

Urinary catheter

5

693/1539

108.70

<0.00001

96%

Random

0.27 [0.02, 0.51]

2.13

0.03*

0.748

Dialysis

3

164/195

0.48

0.79

0%

Fixed

1.54 [0.86, 2.75]

1.47

0.14

0.158

Parenteral nutrition

3

262/733

7.89

0.02

75%

Random

1.73 [0.80, 3.74]

1.39

0.16

0.966

Prior antibiotic use

4

253/1051

3.95

0.27

24%

Fixed

1.61 [1.05, 2.48]

2.19

0.03*

0.265

Carbapenems

5

627/1635

22.29

0.0002

82%

Random

3.84 [2.02, 7.28]

4.12

<0.0001*

0.222

β-lactam+β-lactamase inhibitor

3

537/1373

58.55

<0.00001

97%

Random

1.89 [0.48, 7.48]

0.91

0.37

0.538

Aminoglycosides

4

585/1551

3.50

0.32

14%

Fixed

1.80 [1.28, 2.55]

3.34

0.0008*

0.415

Fluoroquinolones

3

533/1529

14.90

0.0006

87%

Random

1.71 [0.77, 3.77]

1.33

0.18

0.904

Glycopeptides

3

215/811

1.66

0.44

0%

Fixed

1.44 [0.96, 2.14]

1.78

0.07

0.812

  1. Abbreviations: CRKP Carbapenem-resistant Klebsiella pneumoniae, OR Odds ratio, CI Confidence interval, ICU Intensive care unit, HBV Hepatitis B virus, HCV Hepatitis C virus, HCC Hepatocellular carcinoma, CVC Central venous catheter
  2. * Statistically significant differences between groups (α = 0.05)
Back to article page

Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

Contact us