Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis

Table 1 Correlation analysis between antibiotic consumption and the incidence of HO-CDI without a time interval

Class of antibiotics	DDD		DOT
Class of antibiotics	Spearman ρ	P value	Spearman ρ	P value
Total	− 0.08	0.72	− 0.18	0.38
BLBLIs	0.50	0.01*	0.58	0.003*
Third-generation cephalosporins	− 0.33	0.11	− 0.42	0.04*
Fourth-generation cephalosporins	− 0.40	0.05	− 0.46	0.03*
Fluoroquinolones	− 0.14	0.52	− 0.38	0.07
Carbapenems	− 0.29	0.17	− 0.32	0.13
Glycopeptides	− 0.51	0.01*	− 0.54	0.01*
Tigecycline	0.12	0.57	0.10	0.64
Clindamycin	− 0.31	0.15	− 0.37	0.08

BLBLIs β-lactam/β-lactam inhibitors, DDD defined daily dose, DOT days of therapy, HO-CDI healthcare facility-onset C. difficile infection
*P < 0.05

ISSN: 2047-2994