Correlation between antibiotic consumption and the incidence of healthcare facility-onset Clostridioides difficile infection: a retrospective chart review and analysis

Table 3 Regression analysis between antibiotic consumption and the incidence of HO-CDI

Risk factor	Univariate analysis^a		Multivariate analysis^c
Risk factor	Coefficient^b	P value	Coefficient	P value
DDD
BLBLIs	0.11	0.002	0.11	0.002
Carbapenems	− 0.18	0.10
Glycopeptides	− 0.18	0.02
DOT
BLBLIs	0.11	< 0.001	0.11	< 0.001
Third-generation cephalosporins	− 0.11	0.07
Fluoroquinolones	− 0.14	0.08
Carbapenems	− 0.18	0.07
Glycopeptides	− 0.24	0.01

BLBLIs β-lactam/β-lactam inhibitors, DDD defined daily dose, DOT days of therapy, HO-CDI healthcare facility-onset C. difficile infection
^aVariables with P < 0.1 in the univariate analysis were included in the multivariate analysis
^bChanges in the incidence of HO-CDI according to antibiotic consumption
^cR-squared in multivariate analysis: 0.36 [DDD] and 0.42 [DOT]

ISSN: 2047-2994