Mutations in QRDR
|
N (%)
|
FQ
|
No. of isolates with corresponding MIC (mg/L)
|
---|
0.12
|
0.25
|
0.5
|
1
|
2
|
4
|
8
|
---|
GyrA Asp89Asn
|
2 (0.6)
|
MFX
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
2
|
0
|
LFX
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
GyrA Ala90Val
|
76 (24.4)
|
MFX
|
18
|
3
|
16
|
23
|
8
|
8
|
0
|
OFX
|
0
|
0
|
0
|
0
|
17
|
38
|
21
|
LFX
|
0
|
0
|
0
|
0
|
56
|
20
|
0
|
GyrA Ser91Pro
|
33 (10.6)
|
MFX
|
3
|
9
|
10
|
4
|
7
|
0
|
0
|
OFX
|
0
|
0
|
0
|
3
|
7
|
19
|
4
|
LFX
|
0
|
0
|
0
|
4
|
25
|
4
|
0
|
GyrA Asp94Ala
|
17 (5.5)
|
MFX
|
0
|
0
|
10
|
4
|
3
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
2
|
12
|
3
|
LFX
|
0
|
0
|
0
|
0
|
15
|
2
|
0
|
GyrA Asp94Asn
|
19 (6.1)
|
MFX
|
0
|
0
|
4
|
4
|
7
|
4
|
0
|
OFX
|
0
|
0
|
0
|
0
|
3
|
4
|
12
|
LFX
|
0
|
0
|
0
|
0
|
4
|
15
|
0
|
GyrA Asp94Gly
|
96 (30.9)
|
MFX
|
0
|
0
|
10
|
14
|
44
|
28
|
0
|
OFX
|
0
|
0
|
0
|
0
|
3
|
9
|
84
|
LFX
|
0
|
0
|
0
|
0
|
11
|
85
|
0
|
GyrA Asp94His
|
4 (1.3)
|
MFX
|
0
|
0
|
0
|
0
|
0
|
4
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
0
|
4
|
LFX
|
0
|
0
|
0
|
0
|
0
|
4
|
0
|
GyrA Asp94Tyr
|
3 (1.0)
|
MFX
|
0
|
0
|
0
|
0
|
3
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
0
|
3
|
LFX
|
0
|
0
|
0
|
0
|
0
|
3
|
0
|
GyrA Asp94Val
|
8 (2.6)
|
MFX
|
0
|
0
|
0
|
2
|
4
|
2
|
0
|
OFX
|
0
|
0
|
0
|
0
|
2
|
4
|
2
|
LFX
|
0
|
0
|
0
|
0
|
4
|
4
|
0
|
GyrB Ser447Phe
|
2 (0.6)
|
MFX
|
2
|
0
|
0
|
0
|
0
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
2
|
0
|
LFX
|
0
|
0
|
0
|
0
|
2
|
0
|
0
|
GyrB Asp461Asn
|
1 (0.3)
|
MFX
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
LFX
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
GyrB Asp500Asn
|
1 (0.3)
|
MFX
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
LFX
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
GyrB Ala504Thr
|
3 (1.0)
|
MFX
|
0
|
0
|
0
|
0
|
0
|
3
|
0
|
OFX
|
0
|
0
|
0
|
0
|
0
|
0
|
3
|
LFX
|
0
|
0
|
0
|
0
|
0
|
3
|
0
|
WT
|
46 (14.7)
|
MFX
|
0
|
7
|
15
|
12
|
8
|
4
|
0
|
OFX
|
0
|
0
|
0
|
1
|
15
|
21
|
9
|
LFX
|
0
|
0
|
1
|
3
|
24
|
16
|
2
|
Total
|
311 (100.0)
|
MFX
|
23
|
20
|
67
|
63
|
85
|
53
|
0
|
OFX
|
0
|
0
|
0
|
4
|
49
|
112
|
146
|
LFX
|
0
|
0
|
1
|
7
|
143
|
158
|
2
|
- MIC, minimum inhibitory concentration; WT, wild-type; FQ, fluoroquinolone; MFX, moxifloxacin; OFX, ofloxacin; LFX, levofloxacin