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Table 2 Mutations in the quinolone resistance-determining region (QRDR) of gyrA and gyrB and fluoroquinolone MICs

From: Prevalence of extensively drug-resistant tuberculosis in a Chinese multidrug-resistant TB cohort after redefinition

Mutations in QRDR N (%) FQ No. of isolates with corresponding MIC (mg/L)
0.12 0.25 0.5 1 2 4 8
GyrA Asp89Asn 2 (0.6) MFX 0 1 1 0 0 0 0
OFX 0 0 0 0 0 2 0
LFX 0 0 0 0 1 1 0
GyrA Ala90Val 76 (24.4) MFX 18 3 16 23 8 8 0
OFX 0 0 0 0 17 38 21
LFX 0 0 0 0 56 20 0
GyrA Ser91Pro 33 (10.6) MFX 3 9 10 4 7 0 0
OFX 0 0 0 3 7 19 4
LFX 0 0 0 4 25 4 0
GyrA Asp94Ala 17 (5.5) MFX 0 0 10 4 3 0 0
OFX 0 0 0 0 2 12 3
LFX 0 0 0 0 15 2 0
GyrA Asp94Asn 19 (6.1) MFX 0 0 4 4 7 4 0
OFX 0 0 0 0 3 4 12
LFX 0 0 0 0 4 15 0
GyrA Asp94Gly 96 (30.9) MFX 0 0 10 14 44 28 0
OFX 0 0 0 0 3 9 84
LFX 0 0 0 0 11 85 0
GyrA Asp94His 4 (1.3) MFX 0 0 0 0 0 4 0
OFX 0 0 0 0 0 0 4
LFX 0 0 0 0 0 4 0
GyrA Asp94Tyr 3 (1.0) MFX 0 0 0 0 3 0 0
OFX 0 0 0 0 0 0 3
LFX 0 0 0 0 0 3 0
GyrA Asp94Val 8 (2.6) MFX 0 0 0 2 4 2 0
OFX 0 0 0 0 2 4 2
LFX 0 0 0 0 4 4 0
GyrB Ser447Phe 2 (0.6) MFX 2 0 0 0 0 0 0
OFX 0 0 0 0 0 2 0
LFX 0 0 0 0 2 0 0
GyrB Asp461Asn 1 (0.3) MFX 0 0 0 0 1 0 0
OFX 0 0 0 0 0 0 1
LFX 0 0 0 0 0 1 0
GyrB Asp500Asn 1 (0.3) MFX 0 0 1 0 0 0 0
OFX 0 0 0 0 0 1 0
LFX 0 0 0 0 1 0 0
GyrB Ala504Thr 3 (1.0) MFX 0 0 0 0 0 3 0
OFX 0 0 0 0 0 0 3
LFX 0 0 0 0 0 3 0
WT 46 (14.7) MFX 0 7 15 12 8 4 0
OFX 0 0 0 1 15 21 9
LFX 0 0 1 3 24 16 2
Total 311 (100.0) MFX 23 20 67 63 85 53 0
OFX 0 0 0 4 49 112 146
LFX 0 0 1 7 143 158 2
  1. MIC, minimum inhibitory concentration; WT, wild-type; FQ, fluoroquinolone; MFX, moxifloxacin; OFX, ofloxacin; LFX, levofloxacin