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Table 3 The susceptibility and resistance trends of non-fermentative pathogens to antimicrobial agents

From: Blood bacterial resistant investigation collaborative system (BRICS) report: a national surveillance in China from 2014 to 2019

 

All strains (204–2019)

2014

2015

2016

Number

MIC50

MIC90

%R

%S

%R

%S

%R

%S

%R

%S

A. baumannii

MDR

1062

–

–

70.3

–

63.6

–

67.6

–

74.3

–

piperacillin/tazobactam

1062

128

128

55.9

29.7

43.2

53.4

63.7

34.3

45.9

27.6

cefoperazone/sulbactama

1062

64

128

65.6

31.0

58.0

39.8

62.7

34.3

72.0

26.1

ceftazidime

1062

64

128

66.4

32.6

61.4

37.5

64.7

32.4

72.8

26.5

cefepime

1062

64

64

65.3

31.3

56.8

40.9

64.7

33.3

63.8

28.8

imipenem

1062

32

64

63.6

35.9

52.3

46.6

60.8

39.2

71.2

28.8

meropenem

1062

32

64

63.6

35.5

54.5

45.5

59.8

38.2

69.6

28.8

amikacin

1062

64

128

51.5

46.4

46.6

51.1

50.0

50.0

53.3

44.7

gentamicin

1062

32

128

60.4

35.6

56.8

38.6

61.8

38.2

61.9

35.8

ciprofloxacin

1062

32

64

65.2

33.9

56.8

43.2

63.7

36.3

69.6

30.0

levofloxacin

1062

8

32

58.6

35.1

54.5

40.9

50.0

37.3

63.4

30.4

trimethoprim/sulfamethoxazole

1062

4

8

53.8

46.2

46.6

53.4

59.8

40.2

61.1

38.9

polymyxin B

1062

1

2

6.7

93.3

1.1

98.9

2.0

98

12.8

87.2

tigecycline

1062

1

4

4.3

86.5

4.5

92

4.9

90.2

6.6

81.7

P. aeruginosa

MDR

–

–

–

21.1

–

22

–

22.8

–

21.2

–

piperacillin/tazobactam

1044

2

128

10.4

84.5

8.5

81.7

5.9

89.1

9.3

84.5

cefoperazone/sulbactama

1044

8

64

12.4

79.9

13.4

73.2

6.9

84.2

11.9

78.8

ceftazidime/avibactam

362

4

8

2.8

97.2

–

 

–

 

–

 

ceftazidime

1044

4

32

10.2

85.7

9.8

85.4

6.9

89.1

7.3

88.1

cefepime

1044

2

16

7.8

88.7

11.0

85.4

3.0

94.1

5.2

90.7

aztreonam

1044

4

32

14.4

76.9

12.2

78.0

12.9

78.2

10.4

79.8

imipenem

1044

2

32

18.8

79.9

13.5

70.7

12.9

57.4

18.7

80.3

meropenem

1044

0.25

16

13.5

83.2

6.1

92.7

9.9

86.1

10.9

86.5

amikacin

1044

2

8

2.2

97.2

3.7

96.3

3.0

95.0

3.1

96.4

gentamicin

1044

2

8

5.7

89.2

8.5

89.0

8.9

89.1

4.7

91.2

ciprofloxacin

1044

0.25

8

18.2

75.9

12.2

82.9

9.9

86.1

13.5

84.5

levofloxacin

1044

0.5

8

17.2

72.0

18.3

76.8

7.9

84.2

11.9

79.3

polymyxin B

1044

1

2

0

96.5

0

100

0

93.4

0

100

 

2017

2018

2019

Trend

p

%R

%S

%R

%S

%R

%S

A. baumannii

MDR

70.4

–

72.6

–

68.2

–

–

0.841

piperacillin/tazobactam

52.2

35.7

73.6

26.0

54.8

22.9

↑

0.005

cefoperazone/sulbactama

66.1

33.9

68.8

28.4

61.0

32.2

–

0.664

ceftazidime

65.2

33.9

67.3

32.7

62.7

36.0

–

0.438

cefepime

63.5

33.0

69.7

28.8

67.1

30.8

–

0.062

imipenem

63.5

34.8

66.8

33.2

58.9

40.1

–

0.858

meropenem

65.2

34.8

66.8

32.2

59.2

40.1

–

0.920

amikacin

60.0

29.6

52.9

46.2

47.6

52.1

–

0.749

gentamicin

71.3

19.1

62.0

32.7

54.1

42.1

–

0.242

ciprofloxacin

67.8

29.6

69.7

28.8

59.9

39.0

–

0.763

levofloxacin

53.9

33.9

61.1

29.8

58.6

41.1

–

0.428

trimethoprim/sulfamethoxazole

50.4

49.6

56.7

43.3

46.6

53.4

–

0.070

polymyxin B

18.3

81.7

4.8

95.2

1.4

98.6

–

0.046

tigecycline

2.6

93

5.3

88.5

2.1

83.9

–

0.081

P. aeruginosa

MDR

18

–

22.1

–

21.8

–

–

0.488

piperacillin/tazobactam

8.2

84.4

11.4

82.6

13.0

84.8

–

0.028

cefoperazone/sulbactama

10.7

81.1

14.1

82.1

13.5

79.3

–

0.236

ceftazidime/avibactam

–

 

–

 

2.8

97.2

–

NA

ceftazidime

9.0

86.1

12.5

85.3

11.9

83.7

–

0.066

cefepime

9.0

88.5

8.7

88.0

8.8

87.3

–

0.258

aztreonam

14.8

78.7

15.8

73.9

16.6

75.7

–

0.067

imipenem

16.4

82.8

22.8

37.5

19.1

79.8

–

0.345

meropenem

12.3

86.1

15.8

78.8

16.9

79.8

↑

0.001

amikacin

4.9

94.3

1.6

97.8

0.6

99.2

–

0.012

gentamicin

8.2

86.9

6.5

90.8

3.3

88.1

–

0.029

ciprofloxacin

9.8

89.3

20.1

69.0

26.2

65.7

↑

0.000

levofloxacin

11.5

82.0

21.7

57.6

22.1

67.7

↑

0.001

polymyxin B

0

100

0

93.7

0

99.7

–

NA

  1. MDR, multidrug-resistance; NA, no account. ↑, resistance trend with increase. ↓, resistance trend with decrease. –, no significant change
  2. aCriteria as published by the CLSI [8] for cefoperazone also applied to cefoperazone-sulbactam