| All strains (204–2019) | 2014 | 2015 | 2016 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Number | MIC50 | MIC90 | %R | %S | %R | %S | %R | %S | %R | %S | |
A. baumannii | |||||||||||
MDR | 1062 | – | – | 70.3 | – | 63.6 | – | 67.6 | – | 74.3 | – |
piperacillin/tazobactam | 1062 | 128 | 128 | 55.9 | 29.7 | 43.2 | 53.4 | 63.7 | 34.3 | 45.9 | 27.6 |
cefoperazone/sulbactama | 1062 | 64 | 128 | 65.6 | 31.0 | 58.0 | 39.8 | 62.7 | 34.3 | 72.0 | 26.1 |
ceftazidime | 1062 | 64 | 128 | 66.4 | 32.6 | 61.4 | 37.5 | 64.7 | 32.4 | 72.8 | 26.5 |
cefepime | 1062 | 64 | 64 | 65.3 | 31.3 | 56.8 | 40.9 | 64.7 | 33.3 | 63.8 | 28.8 |
imipenem | 1062 | 32 | 64 | 63.6 | 35.9 | 52.3 | 46.6 | 60.8 | 39.2 | 71.2 | 28.8 |
meropenem | 1062 | 32 | 64 | 63.6 | 35.5 | 54.5 | 45.5 | 59.8 | 38.2 | 69.6 | 28.8 |
amikacin | 1062 | 64 | 128 | 51.5 | 46.4 | 46.6 | 51.1 | 50.0 | 50.0 | 53.3 | 44.7 |
gentamicin | 1062 | 32 | 128 | 60.4 | 35.6 | 56.8 | 38.6 | 61.8 | 38.2 | 61.9 | 35.8 |
ciprofloxacin | 1062 | 32 | 64 | 65.2 | 33.9 | 56.8 | 43.2 | 63.7 | 36.3 | 69.6 | 30.0 |
levofloxacin | 1062 | 8 | 32 | 58.6 | 35.1 | 54.5 | 40.9 | 50.0 | 37.3 | 63.4 | 30.4 |
trimethoprim/sulfamethoxazole | 1062 | 4 | 8 | 53.8 | 46.2 | 46.6 | 53.4 | 59.8 | 40.2 | 61.1 | 38.9 |
polymyxin B | 1062 | 1 | 2 | 6.7 | 93.3 | 1.1 | 98.9 | 2.0 | 98 | 12.8 | 87.2 |
tigecycline | 1062 | 1 | 4 | 4.3 | 86.5 | 4.5 | 92 | 4.9 | 90.2 | 6.6 | 81.7 |
P. aeruginosa | |||||||||||
MDR | – | – | – | 21.1 | – | 22 | – | 22.8 | – | 21.2 | – |
piperacillin/tazobactam | 1044 | 2 | 128 | 10.4 | 84.5 | 8.5 | 81.7 | 5.9 | 89.1 | 9.3 | 84.5 |
cefoperazone/sulbactama | 1044 | 8 | 64 | 12.4 | 79.9 | 13.4 | 73.2 | 6.9 | 84.2 | 11.9 | 78.8 |
ceftazidime/avibactam | 362 | 4 | 8 | 2.8 | 97.2 | – |  | – |  | – |  |
ceftazidime | 1044 | 4 | 32 | 10.2 | 85.7 | 9.8 | 85.4 | 6.9 | 89.1 | 7.3 | 88.1 |
cefepime | 1044 | 2 | 16 | 7.8 | 88.7 | 11.0 | 85.4 | 3.0 | 94.1 | 5.2 | 90.7 |
aztreonam | 1044 | 4 | 32 | 14.4 | 76.9 | 12.2 | 78.0 | 12.9 | 78.2 | 10.4 | 79.8 |
imipenem | 1044 | 2 | 32 | 18.8 | 79.9 | 13.5 | 70.7 | 12.9 | 57.4 | 18.7 | 80.3 |
meropenem | 1044 | 0.25 | 16 | 13.5 | 83.2 | 6.1 | 92.7 | 9.9 | 86.1 | 10.9 | 86.5 |
amikacin | 1044 | 2 | 8 | 2.2 | 97.2 | 3.7 | 96.3 | 3.0 | 95.0 | 3.1 | 96.4 |
gentamicin | 1044 | 2 | 8 | 5.7 | 89.2 | 8.5 | 89.0 | 8.9 | 89.1 | 4.7 | 91.2 |
ciprofloxacin | 1044 | 0.25 | 8 | 18.2 | 75.9 | 12.2 | 82.9 | 9.9 | 86.1 | 13.5 | 84.5 |
levofloxacin | 1044 | 0.5 | 8 | 17.2 | 72.0 | 18.3 | 76.8 | 7.9 | 84.2 | 11.9 | 79.3 |
polymyxin B | 1044 | 1 | 2 | 0 | 96.5 | 0 | 100 | 0 | 93.4 | 0 | 100 |
 | 2017 | 2018 | 2019 | Trend | p | |||
---|---|---|---|---|---|---|---|---|
%R | %S | %R | %S | %R | %S | |||
A. baumannii | ||||||||
MDR | 70.4 | – | 72.6 | – | 68.2 | – | – | 0.841 |
piperacillin/tazobactam | 52.2 | 35.7 | 73.6 | 26.0 | 54.8 | 22.9 | ↑ | 0.005 |
cefoperazone/sulbactama | 66.1 | 33.9 | 68.8 | 28.4 | 61.0 | 32.2 | – | 0.664 |
ceftazidime | 65.2 | 33.9 | 67.3 | 32.7 | 62.7 | 36.0 | – | 0.438 |
cefepime | 63.5 | 33.0 | 69.7 | 28.8 | 67.1 | 30.8 | – | 0.062 |
imipenem | 63.5 | 34.8 | 66.8 | 33.2 | 58.9 | 40.1 | – | 0.858 |
meropenem | 65.2 | 34.8 | 66.8 | 32.2 | 59.2 | 40.1 | – | 0.920 |
amikacin | 60.0 | 29.6 | 52.9 | 46.2 | 47.6 | 52.1 | – | 0.749 |
gentamicin | 71.3 | 19.1 | 62.0 | 32.7 | 54.1 | 42.1 | – | 0.242 |
ciprofloxacin | 67.8 | 29.6 | 69.7 | 28.8 | 59.9 | 39.0 | – | 0.763 |
levofloxacin | 53.9 | 33.9 | 61.1 | 29.8 | 58.6 | 41.1 | – | 0.428 |
trimethoprim/sulfamethoxazole | 50.4 | 49.6 | 56.7 | 43.3 | 46.6 | 53.4 | – | 0.070 |
polymyxin B | 18.3 | 81.7 | 4.8 | 95.2 | 1.4 | 98.6 | – | 0.046 |
tigecycline | 2.6 | 93 | 5.3 | 88.5 | 2.1 | 83.9 | – | 0.081 |
P. aeruginosa | ||||||||
MDR | 18 | – | 22.1 | – | 21.8 | – | – | 0.488 |
piperacillin/tazobactam | 8.2 | 84.4 | 11.4 | 82.6 | 13.0 | 84.8 | – | 0.028 |
cefoperazone/sulbactama | 10.7 | 81.1 | 14.1 | 82.1 | 13.5 | 79.3 | – | 0.236 |
ceftazidime/avibactam | – |  | – |  | 2.8 | 97.2 | – | NA |
ceftazidime | 9.0 | 86.1 | 12.5 | 85.3 | 11.9 | 83.7 | – | 0.066 |
cefepime | 9.0 | 88.5 | 8.7 | 88.0 | 8.8 | 87.3 | – | 0.258 |
aztreonam | 14.8 | 78.7 | 15.8 | 73.9 | 16.6 | 75.7 | – | 0.067 |
imipenem | 16.4 | 82.8 | 22.8 | 37.5 | 19.1 | 79.8 | – | 0.345 |
meropenem | 12.3 | 86.1 | 15.8 | 78.8 | 16.9 | 79.8 | ↑ | 0.001 |
amikacin | 4.9 | 94.3 | 1.6 | 97.8 | 0.6 | 99.2 | – | 0.012 |
gentamicin | 8.2 | 86.9 | 6.5 | 90.8 | 3.3 | 88.1 | – | 0.029 |
ciprofloxacin | 9.8 | 89.3 | 20.1 | 69.0 | 26.2 | 65.7 | ↑ | 0.000 |
levofloxacin | 11.5 | 82.0 | 21.7 | 57.6 | 22.1 | 67.7 | ↑ | 0.001 |
polymyxin B | 0 | 100 | 0 | 93.7 | 0 | 99.7 | – | NA |