Table 4 Logistic regression model: risk factors associated with the composite endpoint (transfer to ICU for more than 24 h or hospital death)
From: Antimicrobial stewardship in high-risk febrile neutropenia patients
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
OR [95% CI] | p-value | OR [95% CI] | p-value | |
Sex | ||||
Female | 0.77 [0.45–1.29] | 0.33 | 0.78 [0.44–1.35] | 0.37 |
Male | Ref | Ref | ||
Age | ||||
> 60 years | 1.80 [1.06–2.11] | 0.031 | 2.14 [1.22–3.85] | 0.0093 |
≤ 60 years | Ref | Ref | ||
Charlson comorbidity index | ||||
> 3 | 2.59 [1.54–4.39] | < 0.001 | 3.17 [1.80–5.69] | < 0.001 |
≤ 3 | Ref | Ref | ||
Hematological disease | ||||
Acute myeloid leukemia | 1.37 [0.75–2.40] | 0.29 | 1.67 [0.82–3.34] | 0.15 |
Other | Ref | Ref | ||
Cause of hospitalization | ||||
Intensive or induction chemotherapy | 1.12 [0.57–2.06] | 0.74 | 0.99 [0.45–2.08] | 0.99 |
Other | Ref | Ref | ||
At least one febrile episode during hospital stay | ||||
Yes | 2.53 [1.48–4.44] | < 0.001 | 3.10 [1.75–5.67] | < 0.001 |
No | Ref | Ref | ||
Period | ||||
Post-intervention period | 0.41 [0.23–0.72] | 0.0025 | 0.29 [0.15–0.53] | < 0.001 |
Pre-intervention period | Ref | Ref | ||