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Table 4 Logistic regression model: risk factors associated with the composite endpoint (transfer to ICU for more than 24 h or hospital death)

From: Antimicrobial stewardship in high-risk febrile neutropenia patients

Variables Univariate analysis Multivariate analysis
OR [95% CI] p-value OR [95% CI] p-value
Sex     
 Female 0.77 [0.45–1.29] 0.33 0.78 [0.44–1.35] 0.37
 Male Ref   Ref  
Age     
 > 60 years 1.80 [1.06–2.11] 0.031 2.14 [1.22–3.85] 0.0093
 ≤ 60 years Ref   Ref  
Charlson comorbidity index     
 > 3 2.59 [1.54–4.39] < 0.001 3.17 [1.80–5.69] < 0.001
 ≤ 3 Ref   Ref  
Hematological disease     
 Acute myeloid leukemia 1.37 [0.75–2.40] 0.29 1.67 [0.82–3.34] 0.15
 Other Ref   Ref  
Cause of hospitalization     
 Intensive or induction chemotherapy 1.12 [0.57–2.06] 0.74 0.99 [0.45–2.08] 0.99
 Other Ref   Ref  
At least one febrile episode during hospital stay     
 Yes 2.53 [1.48–4.44] < 0.001 3.10 [1.75–5.67] < 0.001
 No Ref   Ref  
Period     
 Post-intervention period 0.41 [0.23–0.72] 0.0025 0.29 [0.15–0.53] < 0.001
 Pre-intervention period Ref   Ref  
  1. Results of both univariate and multivariate analyses are presented
  2. OR: Odds-ratio; ref: reference