Table 4 Impact of primary antibiotic therapy and duration of antibiotic exposure on detection of class I and class III pathogens in infants born < 32 weeks and < 28 weeks
GA < 32 weeks (n = 911, 64.7%) | GA < 32 weeks (n = 911, 64.7%) | |||||||
|---|---|---|---|---|---|---|---|---|
Adjusted for birthweight, prenatal ABX, pPROM, admitting hospital and mode of delivery | Adjusted for pPROM, admitting hospital and mode of delivery | |||||||
No class I P (n = 770, 54.7%) | At least 1 class I P (n = 141, 10.0%) | OR (95% CI) | p value | No class III P (n = 631, 44.8%) | At least 1 class III P (n = 280, 19.9%) | OR (95% CI) | p value | |
ABX 1st day | 525 (68.2) | 98 (69.5) | 1.0 (0.6–1.8) | 0.89 | 425 (67.4) | 198 (70.7) | 1.1 (0.8–1.6) | 0.58 |
ABX 1-2d (%) | 250 (32.5) | 46 (32.6) | 1 | 0.36 | 194 (30.8) | 102 (36.4) | 1 | 0.09 |
ABX 3-7d (%) | 411 (53.4) | 79 (56.0) | 1.4 (0.8–2.2) | 0.22 | 344 (54.6) | 146 (52.1) | 0.8 (0.5–1.0) | 0.13 |
ABX > 7d (%) | 109 (14.2) | 16 (11.3) | 0.9 (0.4–2.1) | 0.86 | 93 (14.7) | 32 (11.4) | 0.6 (0.3–1.0) | 0.04 |
GA < 28 weeks (n = 428, 30.4%)* | GA < 28 weeks (n = 428, 30.4%)* | |||||||
|---|---|---|---|---|---|---|---|---|
Adjusted for GA, prenatal ABX, pPROM, admitting hospital and mode of delivery | Adjusted for pPROM and mode of Delivery | |||||||
No class I P (n = 350, 24.9%) | At least 1 class I P (n = 78, 5.5%) | OR (95% CI) | p value | No class III P (n = 296, 21.0%) | At least 1 class III P (n = 132, 9.4%) | OR (95% CI) | p value | |
ABX 1st day | 248 (71.0) | 60 (76.9) | 1.3 (0.6–2.8) | 0.45 | 204 (68.9) | 104 (78.8) | 1.2 (0.7–2.2) | 0.37 |
ABX 1-2d (%) | 86 (24.6) | 30 (38.5) | 1 | 0.57 | 75 (25.3) | 41 (31.1) | 1 | 0.23 |
ABX 3-7d (%) | 199 (57.0) | 38 (48.7) | 0.9 (0.5–1.7) | 0.65 | 163 (55.3) | 74 (56.1) | 0.7 (0.4–1.2) | 0.21 |
ABX > 7d (%) | 65 (18.6) | 10 (12.8) | 0.6 (0.2–1.6) | 0.29 | 58 (19.6) | 17 (12.9) | 0.6 (0.3–1.2) | 0.11 |