Skip to main content

Table 2 Length of treatment (LOT) per indication

From: Detecting inappropriate total duration of antimicrobial therapy using semi-automated surveillance

Definitive diagnosis Total (n) Treatment courses with post-discharge treatment (n;%) Percentage of total treatment duration given post-discharge (%;SD)* LOT in days,
(median; IQR)
Recommended course duration** Guideline adherence***
(%)
Treatment courses too long (%)
UTI—Cystitis 420 231 (55) 63 (21) 6.5 (4.0–10.0) 3–7 days 53 31
UTI—Complicated UTI 241 164 (68) 63 (18) 12.0 (7.0–15.0) 7–14 days 60 15
UTI—CAD 28 15 (54) 65 (18) 11.0 (4.8–14.0) 7–14 days 57 14
UTI—Kidney transplant 47 28 (60) 59 (17) 11.0 (5.5–15.0)    
UTI—Other (not specified) 89 60 (67) 68 (18) 13.0 (7.0–15.0    
RTI—CAP-m 328 142 (43) 54 (20) 6.0 (5.0–8.0) 5 days 35 40
RTI—CAP-s 90 17 (19) 46 (24) 5.0 (3.0–7.0) 5 days 29 31
RTI—HAP 41 6 (15) 37 (24) 6.0 (4.0–8.0) 5–7 days 46 24
RTI—Aspiration 82 23 (28) 51 (20) 6.5 (5.0–9.0) 5 days 26 50
RTI—COPD 73 32 (44) 58 (18) 6.0 (3.0–8.0) 7 days 38 14
RTI—Abscess/empyema 23 9 (39) 55 (19) 8.0 (5.5–15.0)    
RTI—Other (not specified) 154 51 (33) 56 (17) 6.0 (3.0–8.8)    
CNS infection 51 7 (14) 70 (21) 8.0 (3.0–11.5)    
CVL infection 29 11 (38) 59 (17) 7.0 (4.0–13.0)    
ENT infection 106 88 (83) 63 (14) 10.0 (9.0–13.0) 7–14 days 75 10
Gastro-enteritis 40 14 (35) 60 (21) 5.0 (3.0–8.0)    
Gynaecological infection 165 91 (55) 68 (16) 7.0 (2.0–11.0)    
Intra-abdominal infection 464 145 (31) 52 (19) 6.0 (4.0–8.0)    
Sepsis e.c.i./unkown 270 53 (20) 56 (20) 4.0 (3.0–7.0)    
Skin or soft tissue infection 336 214 (64) 62 (19) 11.0 (7.0–15.0) 10–14 days 44 16
Other (not specified) 157 49 (31) 63 (19) 6.0 (3.0–10.0)    
Total 3390 1502 (44) 60 (19) 7.0 (4.0–11.0)    
Excluded**** 232       
  1. *Proportions are only given for treatment courses with post-discharge treatment
  2. **Recommended by Dutch guidelines (www.swabid.nl)
  3. *** One additional day was allowed as each calendar day on which a dose was given was counted as a full day of treatment
  4. **** Indications that were rarely selected, i.e. in less than 20 treatment courses, or that would require > 21 days of treatment according to our national guidelines were excluded. These included the following indications: Bone and Joint infection, S. aureus bacteraemia, Endovascular infection, Eye infection, Febrile neutropenia, Fungal infection, Mediastinitis, UTI–cyst infection and chronic prostatatitis
  5. SD Standard deviation, UTI Urinary tract infection, UTI-CAD Catheter-associated urinary tract infection, RTI Respiratory tract infection, CAP-m Community-acquired pneumonia mild-to-moderate severe, CAP-s Community-acquired pneumonia severe, HAP Hospital-acquired pneumonia, COPD Chronic obstructive pulmonary disease, CNS Central nervous system, CVL Central venous line