Pandemic clone USA300 in a Brazilian hospital: detection of an emergent lineage among methicillin-resistant Staphylococcus aureus isolates from bloodstream infections

Table 3 Clinical and microbiological characteristics related to six patients that presented bloodstream infections caused by the pandemic MRSA USA300/ST8/SCCmecIVa lineage

Isolate No	Admission (MM/DD/YY)	Gender/Age (Y)	Comorbidities	Charlson score	Ward	Acquisition	Antimicrobial treatment	Isolation date (MM/DD/YY)	MIC (mg/L)			Virulence	PFGE Pulsotype
Isolate No	Admission (MM/DD/YY)	Gender/Age (Y)	Comorbidities	Charlson score	Ward	Acquisition	Antimicrobial treatment	Isolation date (MM/DD/YY)	OXA	VAN	DAP	Virulence	PFGE Pulsotype
1963†	07/11/17	M/79	SC	5	Gen Surg	HA	VAN	08/05/17	128	1	1	PVL, ACME-I	A1
1967	07/21/17	M/43	SC	2	Int Med	HA	VAN	08/19/17	128	1	1	PVL, ACME-I	A1
1982†	10/26/17	M/68	D, C, SC	10	Emer	HA	VAN	10/27/17	128	1	1	PVL, ACME-I	A1
1988†	11/06/17	M/61	HC	6	Hem	HA	PIP + TAZ	12/05/17	128	2	2	PVL, ACME-I	A2
2013†	06/11/18	F/40	L, ESRD, C, P	3	Emer	HCA	VAN	06/11/18	64	2	1	PVL, ACME-I	A2
2020	07/20/18	M/67	D, C, HC	5	Int Med	HCA	VAN + CEFP	07/22/18	256	0.5	1	PVL, ACME-I	A3

ST, Sequence Type; SCCmec, Staphylococcal cassette chromosome mec; MRSA, Methicillin-resistant S. aureus; M, Month; D, Day; Y, Year; M, Male; F, Female; SC, Solid cancer; D, Diabetes; C, Cardiopathy; HC, Hematological cancer; L, Lupus; ESRD, End stage renal disease; P, Pneumopathy; NA, Not Applicable; Gen Surg, General Surgery; Int Med, Internal medicine; Hem, Hematology; Emer, Emergence Room; VAN, Vancomycin; PIP, Piperacillin; TAZ, Tazobactam; CEFP, Cefepime; HA, Hospital acquired; HCA, Healthcare associated; OXA, Oxacillin; DAP, Daptomycin; MIC, Minimal inhibitory concentration; PVL, Panton-Valentine leukocidin; ACME, Arginine catabolic mobile element; PFGE, Pulsed field gel electrophoresis
^†Death as outcome

ISSN: 2047-2994