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Table 2 Fixed-dose combination antibiotics on the Tanzanian 2021 National Essential Medicines List (NEMLIT) [22]

From: Not recommended fixed-dose antibiotic combinations in low- and middle-income countries – the example of Tanzania

Drug combination

Fixed dose combinations1

Tanzania EML

AWaRe classification and level of allowed prescription2

WHO AWaRe classification3

Not listed on the WHO essential medicine list (EML)

ampicillin-cloxacillin

Caps 250/250 mg

Inj 250/250 mg

Access (B)

Not Recommended

flucloxacillin-amoxicillin

Table 250/250 mg

Access (C)

Not Recommended

ceftriaxone-sulbactam

Inj 1000/500 mg

Watch (D)

Not Recommended

ampicillin-sulbactam

Inj 1000/500 mg

Inj 2000/1000 mg

Inj 10.000/5000 mg

Watch (C)

Access (but not listed on the WHO EML)

Listed on the WHO essential medicine list (EML)

amoxicillin-clavulanic acid

Susp 125/31,25 mg

Susp 250/62,5 mg

Table 500/125 mg

Access (B)

Access (EML)

 

Inj 500/100 mg

Access (C)

 

piperacillin-tazobactam

Inj 2000/250 mg

Inj 4000/500 mg

Watch (S)

Watch (EML)

sulfamethoxazole- trimethoprim

Susp 200/40 mg

Table 400/80 mg

Watch (A)

Access (EML)

  1. Note: Combinations of antimicrobials intended for treatment or prophylaxis of tuberculosis, malaria or viral infections are not included in this overview1. Abbreviations : Caps = capsule, Inj = powder for injection, Susp = power for suspension (dose per 5 mL), Tab = tablet. Tanzania AWaRe classification and level of prescription2: assessed using the Tanzanian 2021 guidelines (21). Level of prescription indicates if there is a restriction with regard to service provision or professional expertise. It indicates the lowest level for which prescription is allowed. B: health centre/clinical officer, C: district hospital/assistant medical officer, D: regional referral hospital/ medical officer, S: tertiary hospital/specialist. WHO EML 2021 AWaRe classification3: assessed using the online database (12) (https://aware.essentialmeds.org/list) and the Excel database document (11) (https://www.who.int/publications/i/item/2021-aware-classification)