Table 3 Adjusted incidence rate ratios (aIRR) of intervention versus baseline periods for the outcome CLABSI with any pathogen stratified by incidence densities (ID) of CLABSI at baseline < or ≥ 0.8 CLABSI/1000 CL-days according to study group (post-hoc analysis)
Outcome/group | Chlorhexidine | Octenidine | Routine care (control arm) | ||||||
|---|---|---|---|---|---|---|---|---|---|
aIRR (95% CI) | P value | P value (Type III) | aIRR (95% CI) | P value | P value (Type III) | aIRR (95% CI) | P value | P value (Type III) | |
CLABSI with any pathogen | |||||||||
ICUs with incidence density of CLABSI at baseline < 0.8 CLABSI/1,000 CL days | n = 11 ICUs | n = 13 ICUs | n = 12 ICUs | ||||||
Baseline period | 1 = reference | 1 = reference | 1 = reference | ||||||
Intervention period | 0.88 (0.42–1.86) | 0.7390 | 0.7373 | 2.59 (1.61–4.17) | < .0001 | 0.0383* | 0.67 (0.3–1.52) | 0.3390 | 0.3626 |
Mechanical ventilation use (per 1%) | 1.01 (0.99–1.03) | 0.4830 | 0.4275 | 1.01 (0.98–1.04) | 0.3760 | 0.3927 | 0.99 (0.96–1.03) | 0.7080 | 0.7800 |
Length of stay (per 1 day) | 0.74 (0.53–1.04) | 0.0830 | 0.1320 | 1.05 (0.65–1.68) | 0.8520 | 0.8602 | 1.13 (0.93–1.38) | 0.2070 | 0.3666 |
ICUs with incidence density of CLABSI at baseline ≥ 0.8 CLABSI/1000 CL days | n = 13 ICUs | n = 11 ICUs | n = 12 ICUs | ||||||
Baseline period | 1 = reference | 1 = reference | 1 = reference | ||||||
Intervention period | 0.61 (0.42–0.88) | 0.0080 | 0.0226* | 0.98 (0.58–1.64) | 0.9380 | 0.9365 | 1.06 (0.63–1.78) | 0.8210 | 0.8242 |
Mechanical ventilation use (per 1%) | 1.02 (1–1.03) | 0.0160 | 0.0912 | 1 (0.99–1.02) | 0.8200 | 0.8405 | 1.01 (0.99–1.02) | 0.4090 | 0.4278 |
Length of stay (per 1 day) | 0.95 (0.85–1.06) | 0.3540 | 0.3631 | 1.09 (1.02–1.17) | 0.0100 | 0.2590 | 1.14 (1.02–1.27) | 0.0250 | 0.0505 |