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Table 1 Descriptive data and outcomes of patients categorized by non-AP after 48 h postoperatively and AP after 48 h postoperatively

From: Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study

Characteristic

Non-AP after 48 h postoperatively (n = 963)

AP after 48 h postoperatively (n = 110)

P value

Patient characteristics

   

Age (years)

59.58 ± 13.29

62.97 ± 13.55

0.012

Sex (male)

535 (55.6)

66 (60.0)

0.374

Diabetes

164 (17.0)

20 (18.2)

0.761

Length of hospital stay

22.90 ± 14.15

25.60 ± 13.23

0.057

Surgical variables

   

Surgical category

  

0.472

 Pancreaticoduodenectomy

481 (49.9)

61 (55.5)

 

 Distal pancreatectomy

315 (32.7)

30 (27.3)

 

 Others

167 (17.3)

19 (17.3)

 

Surgical approach

  

0.303

 Non-endoscopic surgery

833 (86.5)

99 (90.0)

 

 Endoscopic surgery

130 (13.5)

11 (10.0)

 

Emergency

52 (5.4)

6 (5.5)

0.981

ASA score

  

0.006

 0

766 (79.5)

75 (68.2)

 

 1

197 (20.5)

35 (31.8)

 

NNIS score

  

0.018

 1 (0 and 1 point)

819 (85.0)

84 (76.4)

 

 2 (2 and 3 points)

144 (15.0)

26 (23.6)

 

Inpatient department

  

 < 0.001

 Non-pancreatic center

67 (7.0)

24 (21.8)

 

 Pancreatic center

896 (93.0)

86 (78.2)

 

Surgeon

  

 < 0.001

 Doctor 1

65 (6.7)

5 (4.5)

 

 Doctor 2

156 (16.2)

15 (13.6)

 

 Doctor 3

411 (42.7)

41 (37.3)

 

 Doctor 4

73 (7.6)

14 (12.7)

 

 Doctor 5

47 (4.9)

4 (3.6)

 

 Doctor 6

140 (14.5)

6 (5.5)

 

 Others

71 (7.4)

25 (22.7)

 

Surgical time (h)

3.97 ± 1.53

4.18 ± 1.70

0.195

Intraoperative blood loss (mL)

253.24 ± 451.43

329.00 ± 439.76

0.095

Antibiotic

   

Any AP

821 (85.3)

110 (100)

< 0.001

Intraoperative redosing

  

0.531

 Required but no redosing

657 (68.2)

76 (69.1)

 

 Required and redosing

34 (3.5)

6 (5.5)

 

 Not required

272 (28.2)

28 (25.5)

 

AP within 48 h postoperatively

41 (4.3)

92 (83.6)

< 0.001

AP days

0.91 ± 0.52

6.95 ± 3.67

< 0.001

Outcomes

   

SSIs

98 (10.2)

22 (20.0)

0.002

other HAIs

77 (8.0)

11 (10.0)

0.468

  1. AP, antibiotic prophylaxis; ASA, American Society of Anesthesiology; NNIS, National Nosocomial Infections Surveillance; SSIs, surgical site infections; HAIs, healthcare-associated infections