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Table 3 Associations of non-AP after 48 h postoperatively and AP after 48 h postoperatively with HAIs in patients undergoing pancreatic surgery

From: Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study

Exposure

Unadjusted estimate*

Model 1*

Adjusted estimate1

Model 2*

Adjusted estimate2

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

SSIs

      

Postoperative AP

      

 No

1

 

1

 

1

 

 Yes

2.21 (1.32, 3.68)

0.002

2.14 (1.28, 3.59)

0.004

2.13 (0.76, 5.99)

0.153

Other HAIs

      

Postoperative AP

      

 No

1

 

1

 

1

 

 Yes

1.28 (0.66, 2.49)

0.469

1.24 (0.63, 2.42)

0.532

3.69 (0.99, 13.81)

0.053

  1. AP, antibiotic prophylaxis; SSIs, surgical site infections; HAIs, healthcare-associated infections; OR, odds ration; CI, confidence interval; ASA, American Society of Anesthesiology; NNIS, National Nosocomial Infections Surveillance
  2. 1Model 1 was adjusted for age, sex, and diabetes
  3. 2Model 2 was adjusted for age, sex, diabetes, surgical category, surgical approach, surgical time, emergency, ASA score (0 and 1), NNIS score 1 (0 and 1 point) and 2 (2 and 3 points), surgeon, inpatient department, intraoperative blood loss, any AP, intraoperative redosing, AP within 48 h postoperatively, and AP days
  4. *The sample size used for unadjusted estimate, Model 1, and Model 2 is all 1073