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Table 4 Multivariate logistic regression analysis for the association of covariate variables with SSIs and other HAIs

From: Antibiotic prophylaxis after 48 h postoperatively are not associated with decreased surgical site infections and other healthcare associated infections in pancreatic surgery patients: a retrospective cohort study

Exposure

SSIs

Other HAIs

OR (95% CI)

P value

OR (95%C I)

P value

Patient characteristics

    

Age (years)

0.99 (0.98, 1.01)

0.493

1.01 (0.99, 1.03)

0.462

Sex

    

 Male

1

 

1

 

 Female

0.66 (0.43, 1.02)

0.060

0.81 (0.49, 1.32)

0.388

Diabetes

    

 No

1

 

1

 

 Yes

0.81 (0.47, 1.40)

0.454

1.41 (0.80, 2.48)

0.235

Surgical variables

    

Surgical category

    

 Pancreaticoduodenectomy

1

 

1

 

 Distal pancreatectomy

0.45 (0.25, 0.80)

0.007

0.32 (0.15, 0.68)

0.003

 Others

0.59 (0.30, 1.17)

0.132

1.23 (0.62, 2.44)

0.559

Surgical approach

    

 Non-endoscopic surgery

1

 

1

 

 Endoscopic surgery

0.42 (0.17, 1.00)

0.050

0.44 (0.15, 1.25)

0.123

Emergency

    

 No

1

 

1

 

 Yes

1.66 (0.77, 3.60)

0.197

1.06 (0.40, 2.81)

0.906

ASA score

    

 0

1

 

1

 

 1

1.96 (0.73, 5.30)

0.185

2.26 (0.85, 6.01)

0.102

NNIS score

    

 1 (0 and 1 point)

1

 

1

 

 2 (2 and 3 points)

0.79 (0.27, 2.34)

0.675

0.42 (0.14, 1.29)

0.132

Inpatient department

    

 Non-pancreatic center

1

 

1

 

 Pancreatic center

0.72 (0.26, 2.01)

0.532

0.74 (0.24, 2.27)

0.603

Surgeon

    

 Doctor 1

1

 

1

 

 Doctor 2

2.67 (0.86, 8.27)

0.088

3.50 (0.70, 17.47)

0.126

 Doctor 3

1.57 (0.58, 4.23)

0.374

2.56 (0.58, 11.17)

0.213

 Doctor 4

1.24 (0.37, 4.13)

0.725

3.61 (0.73, 17.75)

0.114

 Doctor 5

0.22 (0.02, 1.99)

0.178

3.76 (0.68, 20.90)

0.130

 Doctor 6

1.18 (0.38, 3.64)

0.772

2.45 (0.51, 11.66)

0.261

 Others

1.04 (0.25, 4.24)

0.958

1.70 (0.27, 10.59)

0.570

Surgical time (h)

1.28 (1.09, 1.49)

0.002

1.21 (1.01, 1.45)

0.037

Intraoperative blood loss (mL)

1.00 (1.00, 1.00)

0.984

1.00 (1.00, 1.00)

0.020

Antibiotic

    

Any AP

    

 No

1

 

1

 

 Yes

1.10 (0.57, 2.12)

0.776

0.65 (0.33, 1.25)

0.192

Intraoperative redosing

    

 Required but no redosing

1

 

1

 

 Required and redosing

2.12 (0.92, 4.86)

0.077

0.91 (0.26, 3.23)

0.881

 Not required

1.17 (0.55, 2.50)

0.686

1.15 (0.50, 2.62)

0.740

AP within 48 h postoperatively

    

 No

1

 

1

 

 Yes

1.26 (0.56, 2.85)

0.582

0.98 (0.31, 3.13)

0.978

AP days

0.95 (0.81, 1.11)

0.481

0.78 (0.58, 1.05)

0.098

  1. SSIs, surgical site infections; HAIs, healthcare-associated infections; OR, odds ration; CI, confidence interval; ASA, American Society of Anesthesiology; NNIS, National Nosocomial Infections Surveillance; AP, antibiotic prophylaxis